Methodology of premature chromosome condensation and its potential for relapse prediction in acute leukemia of children and adolescents.
Cancer Genet Cytogenet
; 27(1): 51-61, 1987 Jul.
Article
en En
| MEDLINE
| ID: mdl-3581041
Premature chromosome condensation has been examined as a method for measuring the proliferative potential of bone marrow cells derived from children with acute leukemia with the intention of finding a predictor of relapse. A proliferative potential index (PPI) has been determined for patients with active disease at diagnosis and relapse, as well as at onset of remission and at extramedullary relapse. A modification of the technique established by Hittelman is described, which can be easily performed by the leukemia cytogeneticist. A PPI of 35% or greater is usually obtained for patients at diagnosis or in relapse. At the onset of remission, the PPI declines to values significantly below 35% and during extramedullary relapse the value of the PPI is near normal (12%). The method for the determination of the PPI is given in detail.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia
/
Cromosomas Humanos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Animals
/
Child
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos