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The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches.
Zafari, Narges; Khosravi, Fatemeh; Rezaee, Zahra; Esfandyari, Sahar; Bahiraei, Mohamad; Bahramy, Afshin; Ferns, Gordon A; Avan, Amir.
Afiliación
  • Zafari N; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Khosravi F; Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Rezaee Z; Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Esfandyari S; Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Bahiraei M; Department of Radiology, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran.
  • Bahramy A; Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Ferns GA; Brighton & Sussex Medical School, Division of Medical Education, Sussex, UK.
  • Avan A; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Clin Lab Anal ; 36(8): e24585, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35808903
BACKGROUND: Colorectal cancer (CRC) with a high prevalence is recognized as the fourth most common cause of cancer-related death globally. Over the past decade, there has been growing interest in the network of tumor cells, stromal cells, immune cells, blood vessel cells, and fibroblasts that comprise the tumor microenvironment (TME) to identify new therapeutic interventions. METHODS: Databases, such as Google Scholar, PubMed, and Scopus, were searched to provide an overview of the recent research progress related to targeting the TME as a novel therapeutic approach. RESULTS: Tumor microenvironment as a result of the cross talk between these cells may result in either advantages or disadvantages in tumor development and metastasis, affecting the signals and responses from the surrounding cells. Whilst chemotherapy has led to an improvement in CRC patients' survival, the metastatic aspect of the disease remains difficult to avoid. CONCLUSIONS: The present review emphasizes the structure and function of the TME, alterations in the TME, its role in the incidence and progression of CRC, the effects on tumor development and metastasis, and also the potential of its alterations as therapeutic targets. It should be noted that providing novel studies in this field of research might help us to achieve practical therapeutic strategies based on their interaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Microambiente Tumoral Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Lab Anal Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Microambiente Tumoral Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Lab Anal Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos