Your browser doesn't support javascript.
loading
Structure and Anti-Inflammatory Activity Relationship of Ergostanes and Lanostanes in Antrodia cinnamomea.
Yang, Xin; Wang, Xiang; Lin, Jiachen; Lim, Sophie; Cao, Yujia; Chen, Siyu; Xu, Pingkang; Xu, Chunyuhang; Zheng, Hongling; Fu, Kuo-Chang; Kuo, Chien-Liang; Huang, Dejian.
Afiliación
  • Yang X; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Wang X; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Lin J; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Lim S; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Cao Y; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Chen S; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Xu P; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Xu C; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Zheng H; Department of Food Science and Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
  • Fu KC; AgriGADA Biotech Pte Ltd., 8 Eu Tong Sen Street #17-82, The Central, Singapore 059818, Singapore.
  • Kuo CL; AgriGADA Biotech Pte Ltd., 8 Eu Tong Sen Street #17-82, The Central, Singapore 059818, Singapore.
  • Huang D; Ph.D. Programme for Aging, College of Medicine, China Medical University, Taichun 40678, Taiwan.
Foods ; 11(13)2022 Jun 22.
Article en En | MEDLINE | ID: mdl-35804645
Antrodia cinnamomea is a precious edible mushroom originating from Taiwan that has been popularly used for adjuvant hepatoprotection and anti-inflammation; however, the chemical principle for its anti-inflammatory activity has not been elucidated, which prevents the quality control of related products. Using the RAW264.7 model for the anti-inflammatory activity assay as a guide, we reported the isolation and structural elucidation of three potent anti-inflammatory compounds from isolated ergostanes (16) and lanostanes (6). Their structures were elucidated on the basis of spectroscopic data analysis including NMR and HR-QTOF-MS. Particularly, the absolute configurations of (25R)-antcin K, (25R)-antcin A, versisponic acid D, and (25R)-antcin C were determined by single crystal X-ray diffraction (XRD). The representative and most promising compound antcin A was shown to suppress pro-inflammatory biomolecule release via the down-regulation of iNOS and COX-2 expression through the NF-κB pathway while the mRNA levels of IL-1ß, TNF-α and IL-6 were also decreased. The high dependency on structural variation and activity suggests that there might be special biological targets for antcin A. Our work makes it possible to develop evidence-based dietary supplements from Antrodia cinnamomea based on anti-inflammatory constituents.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza