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Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component.
Bhakta, Pooja; Youssef, Ayman; Bigham, Lindsay; Mallick, Jayati; Bhargava, Peeyush; Rawas, Faisal; Weaver, Dylan; Hunzeker, Zachary E; Dong, Jianli; Willis, Maurice; Qiu, Suimin; Nawgiri, Ranjana; Iguh, Chukwuemeka-Chi C; Lyapichev, Kirill A.
Afiliación
  • Bhakta P; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
  • Youssef A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
  • Bigham L; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Mallick J; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Bhargava P; Department of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
  • Rawas F; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Weaver D; Department of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
  • Hunzeker ZE; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
  • Dong J; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Willis M; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
  • Qiu S; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Nawgiri R; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Iguh CC; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Lyapichev KA; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA. Kilyapic@utmb.edu.
Head Neck Pathol ; 16(4): 1091-1102, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35802244
BACKGROUND: Primary bone lymphoma is a rare type of lymphoid neoplasm with favorable prognosis, where Primary Non Hodgkin Lymphoma of bone (PB-NHL) is most common with the subtype. Amongst PB-NHL, diffuse large Bcell lymphoma represents the majority of cases. The mandible is a very uncommon site of involvement, presenting as a painful bone mass with high suspicion of osteomyelitis. METHODS: We report the case of a 45-year-old male with no significant past medical history who was admitted to the hospital with a large right jaw mass and pain after recent tooth removal. The original tissue biopsy was not diagnostic, and cultures were found to be negative for microorganisms. Due to enlargement of the mass, a fine needle aspiration (FNA) was done. At the time of rapid onsite evaluation of the FNA, atypical lymphoid cells were seen, and material was obtained for flow cytometry (FC) evaluation. This revealed an aberrant clonal B-cell population. The consequent immunohistochemical evaluation of original material supported the diagnosis of PB-NHL. After chemotherapy patient improved. RESULTS: After an extensive English language literature review, we identified and summarized the clinical presentations, diagnostic procedures, histopathologic features, treatment methods, and outcomes of forty-two cases of periodontal PB-NHL. Based on our findings, we propose a set of clinical features at initial presentation to increase the clinical suspicion of periodontal PB-NHL for practitioners. CONCLUSION: Based on our institution's experience and the literature review conclusions, we propose the University of Texas Medical Branch diagnostic approach for PB-NHL and suggest that FNA and FC should be utilized as the essential diagnostic component. The fast and efficient diagnosis of PB-NHL can facilitate the correct treatment and sufficiently improve patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin / Linfoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans / Middle aged Idioma: En Revista: Head Neck Pathol Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin / Linfoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans / Middle aged Idioma: En Revista: Head Neck Pathol Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos