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In silico approaches for drug repurposing in oncology: Protocol for a scoping review of existing evidence.
Cavalcante, Bruno Raphael Ribeiro; Freitas, Raíza Dias; Siquara da Rocha, Leonardo de Oliveira; Rocha, Gisele Vieira; de Carvalho Pachêco, Túlio Cosme; Pereira Ramos, Pablo Ivan; Gurgel Rocha, Clarissa Araújo.
Afiliación
  • Cavalcante BRR; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Brazil.
  • Freitas RD; Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Siquara da Rocha LO; School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Rocha GV; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Brazil.
  • de Carvalho Pachêco TC; Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Pereira Ramos PI; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Brazil.
  • Gurgel Rocha CA; D'Or Institute for Research and Education (IDOR), Salvador, Brazil.
PLoS One ; 17(7): e0271002, 2022.
Article en En | MEDLINE | ID: mdl-35797386
Drug repurposing has been applied in the biomedical field to optimize the use of existing drugs, leading to a more efficient allocation of research resources. In oncology, this approach is particularly interesting, considering the high cost related to the discovery of new drugs with therapeutic potential. Computational methods have been applied to predict associations between drugs and their targets. However, drug repurposing has not always been promising and its efficiency has yet to be proven. Therefore, the present scoping review protocol was developed to screen the literature on how in silico strategies can be implemented in drug repurposing in oncology. The scoping review will be conducted according to the Arksey and O'Malley framework (2005) and the Joanna Briggs Institute recommendations. We will search the PubMed/MEDLINE, Embase, Scopus, and Web of Science databases, as well as the grey literature. We will include peer-reviewed research articles involving in silico strategies applied to drug repurposing in oncology, published between January 1, 2003, and December 31, 2021. Data will be charted and findings described according to review questions. We will report the scoping review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review guidelines (PRISMA-ScR).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Revisión por Pares / Reposicionamiento de Medicamentos Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Revisión por Pares / Reposicionamiento de Medicamentos Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos