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Cannabis Extract Effects on Metabolic Parameters and Gut Microbiota Composition in a Mice Model of NAFLD and Obesity.
Zandani, Gil; Anavi-Cohen, Sarit; Assa-Glazer, Tal; Gorelick, Jonathan; Nyska, Abraham; Sela, Noa; Bernstein, Nirit; Madar, Zecharia.
Afiliación
  • Zandani G; The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
  • Anavi-Cohen S; Peres Academic Center, Rehovot, Israel.
  • Assa-Glazer T; The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
  • Gorelick J; Eastern Regional R&D Center, Kiryat Arba, Israel.
  • Nyska A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Sela N; Department of Plant Pathology and Weed Research, Volcani Center, Rishon LeZion, Israel.
  • Bernstein N; Institute of Soil, Water and Environmental Sciences, Volcani Center, Rishon LeZion, Israel.
  • Madar Z; The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Evid Based Complement Alternat Med ; 2022: 7964018, 2022.
Article en En | MEDLINE | ID: mdl-35795290
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver abnormalities and has been linked with metabolic syndrome hallmarks. Unfortunately, current treatments are limited. This work aimed to elucidate the effects of three cannabis extracts on metabolic alteration and gut microbiota composition in a mouse model of NAFLD and obesity. Male mice were fed with a high-fat diet (HFD) for 12 weeks. Following the establishment of obesity, the HFD-fed group was subdivided into HFD or HFD that was supplemented with one of three cannabis extracts (CN1, CN2, and CN6) for additional 8 weeks. Metabolic parameters together with intestinal microbiota composition were evaluated. Except for several minor changes in gene expression, no profound metabolic effect was found due to cannabis extracts addition. Nevertheless, marked changes were observed in gut microbiota diversity and composition, with CN1 and CN6 exhibiting microbial abundance patterns that are associated with more beneficial outcomes. Taken together, specific cannabis extracts' addition to an HFD results in more favorable modifications in gut microbiota. Although no marked metabolic effect was disclosed, longer treatments duration and/or higher extracts concentrations may be needed. More research is required to ascertain this conjecture and to establish the influence of various cannabis extracts on host health in general and NAFLD in particular.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos