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Glyceraldehyde-derived advanced glycation end-products are associated with left ventricular ejection fraction and brain natriuretic peptide in patients with diabetic adverse cardiac remodeling.
Yasuda, Yuushi; Aoki, Hirofumi; Fujita, Wataru; Fujibayashi, Kousuke; Wakasa, Minoru; Kawai, Yasuyuki; Nakanishi, Hiroaki; Saito, Kazuyuki; Takeuchi, Masayoshi; Kajinami, Kouji.
Afiliación
  • Yasuda Y; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Aoki H; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Fujita W; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Fujibayashi K; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Wakasa M; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Kawai Y; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
  • Nakanishi H; Department of Forensic Medicine, Juntendo University School of Medicine, Tokyo, Japan.
  • Saito K; Department of Forensic Medicine, Juntendo University School of Medicine, Tokyo, Japan.
  • Takeuchi M; Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan.
  • Kajinami K; Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan.
Scand Cardiovasc J ; 56(1): 208-216, 2022 12.
Article en En | MEDLINE | ID: mdl-35792728
Objectives: Glyceraldehyde-derived advanced glycation end-products (Glycer-AGEs) have a strong binding affinity for their cognate receptor and elicit oxidative stress and inflammation. However, it remains unknown whether the levels of Glycer-AGEs correlate with the severity of cardiac function and heart failure in patients with diabetic adverse cardiac remodeling (DbCR). Fourteen heart failure patients with type 2 diabetes mellitus (DM) without other cardiac disorders (DbCR group) were enrolled. Another 14 patients with idiopathic dilated cardiomyopathy (DCM) without DM were served as a control (DCM group). All patients were assessed for serum Glycer-AGEs, nitrotyrosine (NT), and tumor necrosis factor alpha (TNFα) and for plasma brain natriuretic peptide (BNP). The left ventricular ejection fraction (LVEF) was evaluated by echocardiography. Results: The mean serum levels of Glycer-AGEs, NT, and TNFα in the DbCR group were significantly higher than those in the DCM group (for Glycer-AGEs, p = .0073; for NT, p = .005; for TNFα, p < .0001, respectively). In the patients with DbCR, the levels of serum Glycer-AGEs and TNFα were closely associated with LVEF and BNP values. Conclusions: Both Glycer-AGEs and TNFα showed close associations with LVEF and the levels of BNP in patients with DbCR. Glycer-AGEs and TNFα may play a pathological role in the development of DbCR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Insuficiencia Cardíaca Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Scand Cardiovasc J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Insuficiencia Cardíaca Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Scand Cardiovasc J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido