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Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery.
Zhang, Ji-Yuan; Liu, Xiao-Xia; Lin, Jia-Yi; Bao, Xiao-Yan; Peng, Jian-Qing; Gong, Zi-Peng; Luan, Xin; Chen, Yi.
Afiliación
  • Zhang JY; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Liu XX; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Lin JY; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Bao XY; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
  • Peng JQ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • Gong ZP; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China. Electronic address: gzp4012607@126.com.
  • Luan X; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: luanxin@shutcm.edu.cn.
  • Chen Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China. Electronic address: chenyi_19890319@126.com.
Int J Pharm ; 624: 121979, 2022 Aug 25.
Article en En | MEDLINE | ID: mdl-35792230
Oral administration is the most preferred and simplest route, but it is highly challenging due to the numerous barriers in the gastrointestinal tract. To overcome these barriers, nanocarriers have been developed to protect oral drugs. An increased understanding of viral infection has inspired researchers to mimic the viral structures and functions in the design of drug carriers. The virus-inspired nanoparticles (VINs) have been highly optimized based on the viral specific features to enhance the bioavailability of drugs. Herein, we have reviewed the development and design strategies of VINs, as well as a systematic summary for mechanisms and processes of oral absorption and the application of VINs, providing a new perspective on challenges to the clinical translation of oral nano-carriers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Nanopartículas Idioma: En Revista: Int J Pharm Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Nanopartículas Idioma: En Revista: Int J Pharm Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos