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Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.
Sammallahti, Sara; Koopman-Verhoeff, M Elisabeth; Binter, Anne-Claire; Mulder, Rosa H; Cabré-Riera, Alba; Kvist, Tuomas; Malmberg, Anni L K; Pesce, Giancarlo; Plancoulaine, Sabine; Heiss, Jonathan A; Rifas-Shiman, Sheryl L; Röder, Stefan W; Starling, Anne P; Wilson, Rory; Guerlich, Kathrin; Haftorn, Kristine L; Page, Christian M; Luik, Annemarie I; Tiemeier, Henning; Felix, Janine F; Raikkonen, Katri; Lahti, Jari; Relton, Caroline L; Sharp, Gemma C; Waldenberger, Melanie; Grote, Veit; Heude, Barbara; Annesi-Maesano, Isabella; Hivert, Marie-France; Zenclussen, Ana C; Herberth, Gunda; Dabelea, Dana; Grazuleviciene, Regina; Vafeiadi, Marina; Håberg, Siri E; London, Stephanie J; Guxens, Mònica; Richmond, Rebecca C; Cecil, Charlotte A M.
Afiliación
  • Sammallahti S; Department of Adolescent and Child Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Koopman-Verhoeff ME; Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Binter AC; Department of Adolescent and Child Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Mulder RH; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Cabré-Riera A; Institute of Education and Child Studies, Leiden University, Leiden, The Netherlands.
  • Kvist T; Barcelona Institute for Global Health, ISGlobal, Campus Mar, Doctor Aiguader, 88, 08003, Barcelona, Spain. anneclaire.binter@isglobal.org.
  • Malmberg ALK; Universitat Pompeu Fabra, Barcelona, Spain. anneclaire.binter@isglobal.org.
  • Pesce G; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. anneclaire.binter@isglobal.org.
  • Plancoulaine S; Department of Adolescent and Child Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Heiss JA; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Rifas-Shiman SL; Barcelona Institute for Global Health, ISGlobal, Campus Mar, Doctor Aiguader, 88, 08003, Barcelona, Spain.
  • Röder SW; Universitat Pompeu Fabra, Barcelona, Spain.
  • Starling AP; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
  • Wilson R; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  • Guerlich K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  • Haftorn KL; INSERM UMR-S 1136, Team of Epidemiology of Allergic and Respiratory Diseases (EPAR), Institute Pierre Louis of Epidemiology and Public Health (IPLESP), Sorbonne University, Paris, France.
  • Page CM; CRESS, Inserm, INRAE, Université de Paris Cité, Paris, France.
  • Luik AI; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tiemeier H; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Felix JF; Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
  • Raikkonen K; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Lahti J; Center for Lifecourse Epidemiology of Adiposity and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Relton CL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Sharp GC; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.
  • Waldenberger M; Division of Metabolic and Nutritional Medicine, Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital Munich, Munich, Germany.
  • Grote V; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.
  • Heude B; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Annesi-Maesano I; Institute of Health and Society, University of Oslo, Oslo, Norway.
  • Hivert MF; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Zenclussen AC; Department of Mathematics, University of Oslo, Oslo, Norway.
  • Herberth G; Department of Adolescent and Child Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Dabelea D; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Grazuleviciene R; Department of Adolescent and Child Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Vafeiadi M; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Håberg SE; Department of Social and Behavioral Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • London SJ; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Guxens M; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Richmond RC; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  • Cecil CAM; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Clin Epigenetics ; 14(1): 83, 2022 07 05.
Article en En | MEDLINE | ID: mdl-35790973
BACKGROUND: Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. METHODS: We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4-13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. RESULTS: We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10-8). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × 10-8, n = 577) and sleep onset latency (p = 8.8 × 10-9, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716-2539). CONCLUSION: DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Metilación de ADN Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Epigenetics Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Metilación de ADN Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Epigenetics Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania