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The Autism Impact Measure (AIM): Meaningful Change Thresholds and Core Symptom Changes Over One Year from an Online Survey in the U.S.
Silkey, Mariabeth; Durán-Pacheco, Gonzalo; Johnson, Michelle; Liu, Chuang; Clinch, Susanne; Law, Kiely; Loss, Georg.
Afiliación
  • Silkey M; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Durán-Pacheco G; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Johnson M; Roche Products Ltd, Welwyn Garden City, UK. michelle.johnson.mj2@roche.com.
  • Liu C; Hexagon Place, 6 Falcon Way, Shire Park, Welwyn Garden City, AL7 1TW, UK. michelle.johnson.mj2@roche.com.
  • Clinch S; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Law K; Roche Products Ltd, Welwyn Garden City, UK.
  • Loss G; Kennedy Krieger Institute, Baltimore, MD, USA.
J Autism Dev Disord ; 53(9): 3422-3434, 2023 Sep.
Article en En | MEDLINE | ID: mdl-35788854
Validated outcome measures with the capacity to reflect meaningful change are key to assessing potential interventions for autism spectrum disorder (ASD). We derive clinically meaningful change thresholds (MCTs) of the Autism Impact Measure (AIM) and identify factors associated with meaningful change. Baseline and 12-months follow-up survey of caregivers of 2,761 children with ASD aged 3-17 years from the U.S. Simons Foundation Powering Autism Research for Knowledge (SPARK) cohort were analyzed. Using caregiver-reported anchors for change, the 12-month change in estimated AIM MCT (95% confidence interval) for symptom improvement was -4.5 (-7.61, -1.37) points and 9.9 (5.12, 14.59) points for symptom deterioration. These anchor-based MCTs will facilitate future assessments of caregiver-reported change in AIM scores.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastorno del Espectro Autista Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans Idioma: En Revista: J Autism Dev Disord Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastorno del Espectro Autista Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans Idioma: En Revista: J Autism Dev Disord Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos