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Autoantibodies against IFNα in patients with systemic lupus erythematosus and susceptibility for infection: a retrospective case-control study.
Beydon, Maxime; Nicaise-Roland, Pascale; Mageau, Arthur; Farkh, Carine; Daugas, Eric; Descamps, Vincent; Dieude, Philippe; Dossier, Antoine; Goulenok, Tiphaine; Farhi, Fatima; Mutuon, Pierre; Timsit, Jean-Francois; Papo, Thomas; Sacre, Karim.
Afiliación
  • Beydon M; Service de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.
  • Nicaise-Roland P; Service d'Immunologie « Autoimmunité, Hypersensibilités et Biothérapies ¼, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Mageau A; INSERM UMR1152, Université de Paris, Paris, France.
  • Farkh C; Service de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.
  • Daugas E; Laboratoire d'Excellence Inflamex, Faculté de Médecine Site Bichat, Centre de Recherche Sur L'Inflammation, INSERM UMR1149, CNRS ERL8252, Université de Paris, Paris, France.
  • Descamps V; IAME UMR1137, Equipe DeScID, Université de Paris, Paris, France.
  • Dieude P; Service d'Immunologie « Autoimmunité, Hypersensibilités et Biothérapies ¼, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Dossier A; Laboratoire d'Excellence Inflamex, Faculté de Médecine Site Bichat, Centre de Recherche Sur L'Inflammation, INSERM UMR1149, CNRS ERL8252, Université de Paris, Paris, France.
  • Goulenok T; Département de Néphrologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Farhi F; Département de Dermatologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Mutuon P; Département de Rhumatologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Timsit JF; Service de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.
  • Papo T; Service de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.
  • Sacre K; Service de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.
Sci Rep ; 12(1): 11244, 2022 07 04.
Article en En | MEDLINE | ID: mdl-35788140
IFNα and anti-IFNα autoantibodies have been implicated in susceptibility both for systemic lupus erythematosus (SLE) and viral infection. We aimed to analyze the SLE disease phenotype and risk for infection associated with anti-IFN-α IgG autoantibodies in SLE patients In this multidisciplinary retrospective single referral center study, all consecutive patients with SLE admitted between January 1st and November 30th 2020 were considered. All subjects fulfilled the ACR/EULAR 2019 criteria for SLE. Anti-IFNα IgG autoantibodies were quantified at admission by ELISA. Demographic, medical history, laboratory, treatment, and outcome data were extracted from electronic medical records using a standardized data collection form. 180 patients [female 87.2%, median age of 44.4 (34-54.2) years] were included. The median disease duration was 10 years [4-20] with a median SLEDAI score of 2 [0-4] at study time. Fifty-four (30%) patients had a past-history of lupus nephritis. One hundred and forty-four (80%) had received long-term glucocorticoids and 99 (55%) immunosuppressive drugs. Overall, 127 infections-mostly bacterial and viral-were reported in 95 (52.8%) patients. Twenty SLE patients (11.1%) had positive anti-IFNα IgG autoantibodies with a titer ranging from 10 to 103 UA/mL. Age, sex, SLE phenotype and treatment did not significantly differ between SLE patients with or without anti-IFNα. Infection rate was similar in both groups except for tuberculosis which was more frequent in patients with anti-IFNα (20% vs. 3.1%, p = 0.01). The prevalence of autoantibodies against IFNα is high in SLE and associated with a higher frequency of tuberculosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Lupus Eritematoso Sistémico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Lupus Eritematoso Sistémico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido