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Clinical Progression of Baseline Risk States for Mild Cognitive Impairment.
Goldberg, Sarah M; Zhao, Yanji; Cheng, Yu; Weinstein, Andrea M; Gujral, Swathi; Berman, Sarah B; Sweet, Robert A; Butters, Meryl A; Lopez, Oscar L; Snitz, Beth E.
Afiliación
  • Goldberg SM; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Zhao Y; Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA.
  • Cheng Y; Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA.
  • Weinstein AM; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gujral S; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Berman SB; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Sweet RA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Butters MA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Snitz BE; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
J Alzheimers Dis ; 88(4): 1377-1384, 2022.
Article en En | MEDLINE | ID: mdl-35786652
BACKGROUND: This memory-clinic study joins efforts to study earliest clinical signs and symptoms of Alzheimer's disease and related dementias: subjective reports and objective neuropsychological test performance. OBJECTIVE: The memory-clinic denoted two clinical "grey zones": 1) subjective cognitive decline (SCD; n = 107) with normal objective test scores, and 2) isolated low test scores (ILTS; n = 74) without subjective complaints to observe risk for future decline. METHODS: Initial and annual follow-up clinical research evaluations and consensus diagnosis were used to evaluate baseline characteristics and clinical progression over 2.7 years, compared to normal controls (NC; n = 117). RESULTS: The ILTS group was on average older than the NC and SCD groups. They had a higher proportion of people identifying as belonging to a minoritized racial group. The SCD group had significantly more years of education than the ILTS group. Both ILTS and SCD groups had increased risk of progression to mild cognitive impairment. Older age, minoritized racial identity, and baseline cognitive classification were risk factors for progression. CONCLUSION: The two baseline risk groups look different from each other, especially with respect to demographic correlates, but both groups predict faster progression than controls, over and above demographic differences. Varied presentations of early risk are important to recognize and may advance cognitive health equity in aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos