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Gambogic Acid Induces HO-1 Expression and Cell Apoptosis through p38 Signaling in Oral Squamous Cell Carcinoma.
Su, Shih-Chi; Chen, Yi-Tzu; Hsieh, Yi-Hsien; Yang, Wei-En; Su, Chun-Wen; Chiu, Wen-Yu; Yang, Shun-Fa; Lin, Chiao-Wen.
Afiliación
  • Su SC; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.
  • Chen YT; School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
  • Hsieh YH; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
  • Yang WE; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
  • Su CW; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • Chiu WY; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
  • Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • Lin CW; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Am J Chin Med ; 50(6): 1663-1679, 2022.
Article en En | MEDLINE | ID: mdl-35786173
Gambogic acid (GA), a natural and bioactive compound from the gamboge resin, has been reported to exhibit many oncostatic activities against several types of malignancies. However, its effects on the progression of oral squamous cell carcinoma (OSCC) remain largely unexplored. To fill this gap, we investigated the anticancer role of GA and molecular mechanisms underlying GA's actions in combating oral cancer. We found that GA negatively regulated the viability of OSCC cells, involving induction of the sub-G1 phase and cell apoptosis. In addition, a specific signature of apoptotic proteome, such as upregulation of heme oxygenase-1 (HO-1) and activation of caspase cascades, was identified in GA-treated OSCC. Moreover, such induction of HO-1 expression and caspase cleavage by GA was significantly diminished through the pharmacological inhibition of p38 kinase. In conclusion, these results demonstrate that GA promotes cell apoptosis in OSCC, accompanied with the activation of a p38-dependent apoptotic pathway. Our findings provide potential avenues for the use of GA with high safety and therapeutic implications in restraining oral cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Chin Med Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Chin Med Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur