Exposure to arsenic and respiratory cancer. A reanalysis.
Am J Epidemiol
; 125(6): 929-38, 1987 Jun.
Article
en En
| MEDLINE
| ID: mdl-3578251
This paper is a reanalysis of data on the respiratory cancer mortality experience of 2,802 men who worked one year or more during the period 1940-1964 at a copper smelter in Tacoma, Washington. Exposure estimates presented earlier have been recalculated and perhaps improved. While the previous analysis showed only a weak relation between respiratory cancer and arsenic exposure, use of new data shows a much stronger relation--but one that is concave downward and not ordinarily considered for environmental exposure and cancer. This new analysis indicates that arsenic is probably more potent as a carcinogen than indicated by other studies. It also demonstrates the distinction between airborne arsenic and the bioavailability of arsenic, and the importance of this distinction for risk assessment. When a dose-response relation is based on airborne concentrations of arsenic, it is clearly concave downward, but when based on urine concentrations, it appears to be linear.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arsénico
/
Neoplasias del Sistema Respiratorio
/
Cobre
/
Metalurgia
/
Enfermedades Profesionales
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Epidemiol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos