Your browser doesn't support javascript.
loading
Immunomodulatory role of T helper cells in rheumatoid arthritis : a comprehensive research review.
Luo, Pan; Wang, Peixu; Xu, Jiawen; Hou, Weikun; Xu, Peng; Xu, Ke; Liu, Lin.
Afiliación
  • Luo P; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Wang P; Department of Orthopedics, China-Japan Friendship Hospital, China-Japan Friendship Institute of Clinical Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Graduate School of Peking Union Medical College, Beijing, China.
  • Xu J; Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
  • Hou W; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Xu P; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Xu K; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Liu L; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.
Bone Joint Res ; 11(7): 426-438, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35775145
Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells and their reciprocal immune interactions with proinflammatory cytokines. T cells, an essential part of the immune system, play an important role in RA. T helper 1 (Th1) cells induce interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and interleukin (IL)-2, which are proinflammatory cytokines, leading to cartilage destruction and bone erosion. Th2 cells primarily secrete IL-4, IL-5, and IL-13, which exert anti-inflammatory and anti-osteoclastogenic effects in inflammatory arthritis models. IL-22 secreted by Th17 cells promotes the proliferation of synovial fibroblasts through induction of the chemokine C-C chemokine ligand 2 (CCL2). T follicular helper (Tfh) cells produce IL-21, which is key for B cell stimulation by the C-X-C chemokine receptor 5 (CXCR5) and coexpression with programmed cell death-1 (PD-1) and/or inducible T cell costimulator (ICOS). PD-1 inhibits T cell proliferation and cytokine production. In addition, there are many immunomodulatory agents that promote or inhibit the immunomodulatory role of T helper cells in RA to alleviate disease progression. These findings help to elucidate the aetiology and treatment of RA and point us toward the next steps. Cite this article: Bone Joint Res 2022;11(7):426-438.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Bone Joint Res Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Bone Joint Res Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido