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Identification of risk factors for delirium, cognitive decline, and dementia after cardiac surgery (FINDERI-find delirium risk factors): a study protocol of a prospective observational study.
Sadlonova, Monika; Vogelgsang, Jonathan; Lange, Claudia; Günther, Irina; Wiesent, Adriana; Eberhard, Charlotte; Ehrentraut, Julia; Kirsch, Mareike; Hansen, Niels; Esselmann, Hermann; Timäus, Charles; Asendorf, Thomas; Breitling, Benedict; Chebbok, Mohammed; Heinemann, Stephanie; Celano, Christopher; Kutschka, Ingo; Wiltfang, Jens; Baraki, Hassina; von Arnim, Christine A F.
Afiliación
  • Sadlonova M; Department of Cardiovascular and Thoracic Surgery, University of Göttingen Medical Center, Robert-Koch-Street 40, 37075, Göttingen, Germany. monika.sadlonova@med.uni-goettingen.de.
  • Vogelgsang J; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany. monika.sadlonova@med.uni-goettingen.de.
  • Lange C; DZHK (German Center for Cardiovascular Research), Partner Site, Göttingen, Germany. monika.sadlonova@med.uni-goettingen.de.
  • Günther I; Department of Psychiatry, Massachusetts General Hospital, Boston, USA. monika.sadlonova@med.uni-goettingen.de.
  • Wiesent A; Department of Psychiatry, Harvard Medical School, Boston, USA. monika.sadlonova@med.uni-goettingen.de.
  • Eberhard C; Department of Psychiatry, Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Boston, USA.
  • Ehrentraut J; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Kirsch M; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Hansen N; Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany.
  • Esselmann H; Department of Cardiovascular and Thoracic Surgery, University of Göttingen Medical Center, Robert-Koch-Street 40, 37075, Göttingen, Germany.
  • Timäus C; Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany.
  • Asendorf T; Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany.
  • Breitling B; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Chebbok M; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Heinemann S; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Celano C; Department of Medical Statistics, University of Göttingen Medical Center, Göttingen, Germany.
  • Kutschka I; Department of Psychiatry and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany.
  • Wiltfang J; Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany.
  • Baraki H; Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
  • von Arnim CAF; Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany.
BMC Cardiovasc Disord ; 22(1): 299, 2022 06 30.
Article en En | MEDLINE | ID: mdl-35773648
BACKGROUND: Postoperative delirium is a common complication of cardiac surgery associated with higher morbidity, longer hospital stay, risk of cognitive decline, dementia, and mortality. Geriatric patients, patients undergoing cardiac surgery, and intensive care patients are at a high risk of developing postoperative delirium. Gold standard assessments or biomarkers to predict risk factors for delirium, cognitive decline, and dementia in patients undergoing cardiac surgery are not yet available. METHODS: The FINDERI trial (FINd DElirium RIsk factors) is a prospective, single-center, observational study. In total, 500 patients aged ≥ 50 years undergoing cardiac surgery at the Department of Cardiovascular and Thoracic Surgery of the University of Göttingen Medical Center will be recruited. Our primary aim is to validate a delirium risk assessment in context of cardiac surgery. Our secondary aims are to identify specific preoperative and perioperative factors associated with delirium, cognitive decline, and accelerated dementia after cardiac surgery, and to identify blood-based biomarkers that predict the incidence of postoperative delirium, cognitive decline, or dementia in patients undergoing cardiac surgery. DISCUSSION: This prospective, observational study might help to identify patients at high risk for delirium prior to cardiac surgery, and to identify important biological mechanisms by which cardiac surgery is associated with delirium. The predictive value of a delirium screening questionnaire in cardiac surgery might be revealed. Finally, the identification of specific blood biomarkers might help to predict delirium, cognitive decline, and dementia in patients undergoing cardiac surgery. TRIAL REGISTRATION: Ethics approval for this study was obtained from the IRB of the University of Göttingen Medical Center. The investigators registered this study in the German Clinical Trials Register (DRKS; https://www.drks.de ) (DRKS00025095) on April 19th, 2021.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delirio / Demencia / Disfunción Cognitiva / Procedimientos Quirúrgicos Cardíacos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Ethics Límite: Aged / Humans / Middle aged Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delirio / Demencia / Disfunción Cognitiva / Procedimientos Quirúrgicos Cardíacos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Ethics Límite: Aged / Humans / Middle aged Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido