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[High risk localized and locally advanced prostate cancer: Long-term oncological outcomes after prostatectomy]. / Cancer de la prostate localisé de haut risque et localement avancé : résultats oncologiques à long terme de la prostatectomie.
Miro-Padovani, M; Batista da Costa, J; Salomon, L; Ingels, A; De la Taille, A.
Afiliación
  • Miro-Padovani M; Service d'urologie et de transplantation rénale, faculté de médecine Paris 12, CHU d'Henri-Mondor, 51, avenue Marechal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address: mickael.miro-padovani@aphp.fr.
  • Batista da Costa J; Service d'urologie et de transplantation rénale, faculté de médecine Paris 12, CHU d'Henri-Mondor, 51, avenue Marechal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address: jose.bdc@me.com.
  • Salomon L; Service d'urologie, centre hospitalier Mont-de-Marsan, 417, avenue Pierre-de-Coubertin, 40024 Mont-de-Marsan, France. Electronic address: laurent.salomon@ch-mdm.fr.
  • Ingels A; Service d'urologie et de transplantation rénale, faculté de médecine Paris 12, CHU d'Henri-Mondor, 51, avenue Marechal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address: alexandre.ingels@gmail.com.
  • De la Taille A; Service d'urologie et de transplantation rénale, faculté de médecine Paris 12, CHU d'Henri-Mondor, 51, avenue Marechal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address: adelataille@hotmail.com.
Prog Urol ; 32(10): 702-710, 2022 Sep.
Article en Fr | MEDLINE | ID: mdl-35773175
INTRODUCTION: High risk localized and locally advanced forms are responsible for the vast majority of specific deaths from prostate cancer among non-metastatic diseases at diagnosis. No randomized study has yet been published to establish the best local treatment in terms of survival. AIM: Conduct a large-volume cohort study with long-term follow-up to analyze specific and overall survival outcomes after surgery. METHOD: A single-center retrospective study of all patients operated on for localized high-risk and locally advanced prostate cancer was performed. Actuarial survival analyses and multivariate analyses were performed to discern predictive risk factors. RESULTS: Five hundred patients were included. MRI stage was≥iT3a in 40.7% of cases and 50.2% of patients had a Gleason score≥8 on biopsy. The mean follow-up was 63.1 months. The overall, specific and biological recurrence-free survival were respectively 77.6%, 93.9% and 26.8% at 10 years. A PSA level≥20, a Gleason score on biopsy≥9 and a MRI stage≥iT3a were significantly associated with the 10-years biological recurrence risk. CONCLUSION: This study shows very good long-term oncological results. In the absence of a randomized controlled trial, these results suggest the primary role of surgery in this indication and support the evolution of current practices. We pointed out very pejorative features that might help selection of the best candidates for surgical treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostatectomía / Neoplasias de la Próstata Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: Fr Revista: Prog Urol Asunto de la revista: UROLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prostatectomía / Neoplasias de la Próstata Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: Fr Revista: Prog Urol Asunto de la revista: UROLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Francia