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[Perspectives for future development of the kidney paired donation programme in France]. / Perspectives pour une évolution du programme de don croisé de reins en France.
Combe, Julien; Hiller, Victor; Tercieux, Olivier; Audry, Benoît; Baudet, Jules; Malaquin, Géraldine; Kerbaul, François; Antoine, Corinne; Macher, Marie-Alice; Jacquelinet, Christian; Bastien, Olivier; Pastural, Myriam.
Afiliación
  • Combe J; École polytechnique, route de Saclay, 91120 Palaiseau, France.
  • Hiller V; Université Paris 2 Panthéon-Assas, LEMMA, 4, rue Blaise-Desgoffe, 75006 Paris, France.
  • Tercieux O; Paris School of Economics and CNRS, 48, boulevard Jourdan, 75014 Paris, France.
  • Audry B; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Baudet J; École polytechnique, route de Saclay, 91120 Palaiseau, France.
  • Malaquin G; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Kerbaul F; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Antoine C; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Macher MA; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Jacquelinet C; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Bastien O; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France.
  • Pastural M; Agence de la biomédecine, 1, avenue du Stade-de-France, 93212 Saint-Denis, France. Electronic address: myriam.pastural@biomedecine.fr.
Nephrol Ther ; 18(4): 270-277, 2022 Jul.
Article en Fr | MEDLINE | ID: mdl-35773141
Almost one third of kidney donation candidates are incompatible (HLA and/or ABO) with their directed recipient. Kidney paired donation allows potential donors to be exchanged and gives access to a compatible kidney transplant. The Bioethics Law of 2011 authorised kidney paired donation in France with reciprocity between 2 incompatible "donor-recipient" pairs. A limited number of transplants have been performed due to a too restricted authorization compared to other European practices. This study presents the perspectives of the new Bioethics Law, enacted in 2021, which increases the authorised practices for kidney paired donation in France. The two simulated evolutions are the increase of the number of pairs involved in a kidney paired donation to 6 (against 2 currently) and the use of a deceased donor as a substitution to one of living donor. Different scenarios are simulated using data from the Agence de la Biomedecine; incompatible pairs registered in the kidney paired donation programme in France between December 2013 and February 2018 (78 incompatible pairs), incompatible transplants performed during the same period (476 incompatible pairs) and characteristics of deceased donors as well as proposals made over this period. Increasing the number of pairs has a limited effect on the number of transplants, which increases from 18 (23% of recipients) in the current system to 25 (32% of recipients) when 6 pairs can be involved. The use of a deceased donor significantly increases the number of transplants to 41 (52% of recipients). This study makes it possible to evaluate the increase in possibilities of kidney transplants by kidney paired donation following the new bioethics law. A working group and an information campaign for professionals and patients will be necessary for its implementation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obtención de Tejidos y Órganos / Trasplante de Riñón Aspecto: Ethics Límite: Humans País/Región como asunto: Europa Idioma: Fr Revista: Nephrol Ther Asunto de la revista: NEFROLOGIA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obtención de Tejidos y Órganos / Trasplante de Riñón Aspecto: Ethics Límite: Humans País/Región como asunto: Europa Idioma: Fr Revista: Nephrol Ther Asunto de la revista: NEFROLOGIA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia