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Inhibitory Effects of Compounds from Plumula nelumbinis on Biofilm and Quorum Sensing Against P. aeruginosa.
Chen, Honggeng; Wu, Liangcai; Su, Yalun; Huang, Zhilin; Wang, Likang; Xia, Zhiyun; Huang, Huarong; Wang, Wenxia; Fang, Jingyan; Gu, Zimin; Sun, Pinghua; Zheng, Junxia.
Afiliación
  • Chen H; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Wu L; Department of Dermatology, the Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, People's Republic of China.
  • Su Y; College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China.
  • Huang Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Wang L; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Xia Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Huang H; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Wang W; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Fang J; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Gu Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
  • Sun P; College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China. pinghuasunny@163.com.
  • Zheng J; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China. junxiazheng@gdut.edu.cn.
Curr Microbiol ; 79(8): 236, 2022 Jun 29.
Article en En | MEDLINE | ID: mdl-35767197
Quorum sensing (QS), which controls the survival and virulence of Pseudomonas aeruginosa, including the formation of biofilm, is considered to be a new target to overcome pathogens. The aim of this study was to identify new QS inhibitors against P. aeruginosa and provide potential treatments for clinical infections. In this study, 25 compounds were isolated from Plumula nelumbini. Among these compounds, C25 showed the most significant biofilm inhibition activity, reaching 44.63% at 100 µM without inhibiting bacterial growth. Furthermore, C25 showed significant inhibition activity of rhamnolipid, pyocyanin, and elastase. Further mechanistic studies have confirmed that C25 could downregulate key genes in the QS system, including lasI, lasR, lasA, lasB, and pqsR, and Molecular docking studies have shown that C25 can bind to the active sites of the LasR and PqsR receptors. The present study suggests that C25 is a promising QS inhibitor for treating P. aeruginosa infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Percepción de Quorum Tipo de estudio: Prognostic_studies Idioma: En Revista: Curr Microbiol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Percepción de Quorum Tipo de estudio: Prognostic_studies Idioma: En Revista: Curr Microbiol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos