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4-Hydroxydibenzyl: a novel metabolite from the human gut microbiota after consuming resveratrol.
Iglesias-Aguirre, C E; Vallejo, F; Beltrán, D; Berná, J; Puigcerver, J; Alajarín, M; Selma, M V; Espín, J C.
Afiliación
  • Iglesias-Aguirre CE; Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es.
  • Vallejo F; Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es.
  • Beltrán D; Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es.
  • Berná J; Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, 30100 Murcia, Spain.
  • Puigcerver J; Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, 30100 Murcia, Spain.
  • Alajarín M; Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, 30100 Murcia, Spain.
  • Selma MV; Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es.
  • Espín JC; Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es.
Food Funct ; 13(14): 7487-7493, 2022 Jul 18.
Article en En | MEDLINE | ID: mdl-35762857
Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol, lunularin (LUNU), and (or) 3,4'-dihydroxy-trans-stilbene (DHST). We describe here for the first time that LUNU can be further dehydroxylated, but only at the 3-position, to yield 4-hydroxydibenzyl, a novel metabolite found in human urine after RSV intake in 41 out of 59 healthy participants. In contrast, DHST was not further dehydroxylated, and thus, 4-hydroxy-trans-stilbene was not detected as a gut microbial metabolite of RSV. Faecal in vitro incubations confirmed the in vivo results.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estilbenos / Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: Food Funct Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estilbenos / Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: Food Funct Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido