PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency.

Lau, Cia-Hin; Huang, Siping; Lam, Raymond H W; Tin, Chung

Lau, Cia-Hin; Huang, Siping; Lam, Raymond H W; Tin, Chung.

Afiliación

Lau CH; Department of Biomedical Engineering, City University of Hong Kong, Room P6416, Yeung Kin Man Academic Building, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, SAR, China.
Huang S; Department of Biomedical Engineering, City University of Hong Kong, Room P6416, Yeung Kin Man Academic Building, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, SAR, China.
Lam RHW; Department of Biomedical Engineering, City University of Hong Kong, Room P6416, Yeung Kin Man Academic Building, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, SAR, China.
Tin C; Department of Biomedical Engineering, City University of Hong Kong, Room P6416, Yeung Kin Man Academic Building, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, SAR, China.

Mol Ther Methods Clin Dev ; 26: 26-37, 2022 Sep 08.

Article en En | MEDLINE | ID: mdl-35755943

Palabras clave

SpRY; VP16; VP64; adeno-associated virus; base editing; dual base editor; nCas9-NG; positive feedback

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Mol Ther Methods Clin Dev Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google