Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.

Shen, Pei; Wang, Yezhi; Jia, Xiangxiang; Xu, Pengfei; Qin, Lian; Feng, Xi; Li, Zhiyu; Qiu, Zhixia

Shen, Pei; Wang, Yezhi; Jia, Xiangxiang; Xu, Pengfei; Qin, Lian; Feng, Xi; Li, Zhiyu; Qiu, Zhixia.

Afiliación

Shen P; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Wang Y; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Jia X; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Xu P; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Qin L; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Feng X; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China.
Li Z; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 21009, PR China. Electronic address: zhiyuli@cpu.edu.cn.
Qiu Z; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 21009, PR China. Electronic address: zxqiu@cpu.edu.cn.

Eur J Med Chem ; 239: 114551, 2022 Sep 05.

Article en En | MEDLINE | ID: mdl-35749986

Asunto(s)

Neoplasias Hematológicas; Enfermedades del Sistema Inmune; Inhibidores de las Cinasas Janus; Neoplasias Hematológicas/tratamiento farmacológico; Humanos; Janus Quinasa 2/metabolismo; Inhibidores de las Cinasas Janus/farmacología; Inhibidores de las Cinasas Janus/uso terapéutico; Quinasas Janus; Factores de Transcripción STAT/metabolismo; Factores de Transcripción STAT/farmacología; Transducción de Señal

Palabras clave

Autoimmune and inflammatory diseases; Designed multiple ligand; Dual JAK inhibitors; Medicinal chemistry; Solid and hematological malignancies

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hematológicas / Inhibidores de las Cinasas Janus / Enfermedades del Sistema Inmune Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article Pais de publicación: Francia

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