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Effect of upfront intensive therapy on oncological outcomes in older patients with high tumor burden metastatic castration-sensitive prostate cancer: A multicenter retrospective study.
Miura, Yuki; Hatakeyama, Shingo; Narita, Shintaro; Kimura, Takahiro; Hata, Kenichi; Yanagisawa, Takafumi; Tanaka, Toshikazu; Ishi, Noritaka; Kawamura, Sadafumi; Hoshi, Senji; Ishidoya, Shigeto; Mitsuzuka, Koji; Ito, Akihiro; Tsuchiya, Norihiko; Egawa, Shin; Habuchi, Tomonori; Ohyama, Chikara.
Afiliación
  • Miura Y; Department of Urology, Hirosaki University School of Medicine, Hirosaki, Japan.
  • Hatakeyama S; Department of Urology, Hirosaki University School of Medicine, Hirosaki, Japan.
  • Narita S; Department of Urology, Akita University School of Medicine, Akita, Japan.
  • Kimura T; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
  • Hata K; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
  • Yanagisawa T; Department of Urology, Atsugi City Hospital, Atsugi, Kanagawa, Japan.
  • Tanaka T; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
  • Ishi N; Department of Urology, Aomori Prefectural Central Hospital, Aomori, Japan.
  • Kawamura S; Department of Urology, Hirosaki University School of Medicine, Hirosaki, Japan.
  • Hoshi S; Department of Urology, Miyagi Cancer Center, Natori, Japan.
  • Ishidoya S; Department of Urology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
  • Mitsuzuka K; Department of Urology, Sendai City Hospital, Sendai, Japan.
  • Ito A; Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
  • Tsuchiya N; Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
  • Egawa S; Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
  • Habuchi T; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
  • Ohyama C; Department of Urology, Akita University School of Medicine, Akita, Japan.
Prostate ; 82(13): 1304-1312, 2022 09.
Article en En | MEDLINE | ID: mdl-35747992
BACKGROUND: The effect of upfront intensive therapy on the prognosis of older patients with metastatic castration-sensitive prostate cancer (mCSPC) remains unclear. Thus, we assessed the impact of older age (≥75 years) on oncological outcomes in mCSPC patients with a high tumor burden. METHODS: This multicenter retrospective study included 252 patients aged ≥75 years treated with either upfront or conventional therapy between 2014 and 2021. We compared castration-resistant prostate cancer (CRPC)-free survival (FS) and overall survival (OS) between patients with androgen deprivation therapy (ADT) plus upfront intensive therapy (docetaxel [DTX] or abiraterone acetate [ABI] plus prednisolone) and conventional therapy (ADT monotherapy or ADT combined with bicalutamide). We evaluated the effect of upfront intensive therapy on prognosis by multivariable Cox regression analysis. RESULTS: The 231 patients enrolled in our study were classified in the conventional group (n = 148) or the upfront group (n = 104; DTX = 27 and ABI = 77). The upfront group had significantly prolonged CRPC-FS and OS compared with the conventional group, and this was also the case in the background-adjusted multivariable Cox regression analysis. CONCLUSION: Patients aged ≥75 years who received upfront intensive therapy had significantly longer CRPC-FS and OS compared with similar age patients treated with conventional therapy in real-world practice. The oncological benefit may not diminish in this older population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Humans / Male Idioma: En Revista: Prostate Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Humans / Male Idioma: En Revista: Prostate Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos