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A Novel Classification Model for Lower-Grade Glioma Patients Based on Pyroptosis-Related Genes.
Shen, Yusheng; Chi, Hao; Xu, Ke; Li, Yandong; Yin, Xisheng; Chen, Shi; Yang, Qian; He, Miao; Zhu, Guohua; Li, Xiaosong.
Afiliación
  • Shen Y; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
  • Chi H; Clinical Medicine College, Southwest Medical University, Luzhou 646000, China.
  • Xu K; Department of Oncology, Chongqing General Hospital, Chongqing 401147, China.
  • Li Y; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
  • Yin X; Clinical Medicine College, Southwest Medical University, Luzhou 646000, China.
  • Chen S; Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • Yang Q; Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • He M; Laboratory Animal Center of Chongqing Medical University, Chongqing 400016, China.
  • Zhu G; Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
  • Li X; Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Brain Sci ; 12(6)2022 May 28.
Article en En | MEDLINE | ID: mdl-35741587
Recent studies demonstrated that pyroptosis plays a crucial role in shaping the tumor-immune microenvironment. However, the influence of pyroptosis on lower-grade glioma regarding immunotherapy and targeted therapy is still unknown. This study analyzed the variations of 33 pyroptosis-related genes in lower-grade glioma and normal tissues. Our study found considerable genetic and expression alterations in heterogeneity among lower-grade gliomas and normal brain tissues. There are two pyroptosis phenotypes in lower-grade glioma, and they exhibited differences in cell infiltration characteristics and clinical characters. Then, a PyroScore model using the lasso-cox method was constructed to measure the level of pyroptosis in each patient. PyroScore can refine the lower-grade glioma patients with a stratified prognosis and a distinct tumor immune microenvironment. Pyscore may also be an effective factor in predicting potential therapeutic benefits. In silico analysis showed that patients with a lower PyroScore are expected to be more sensitive to targeted therapy and immunotherapy. These findings may enhance our understanding of pyroptosis in lower-grade glioma and might help optimize risk stratification for the survival and personalized management of lower-grade glioma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza