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Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.
Gupta, Anjali; Saraiya, Veeral; Deveaux, April; Oyekunle, Taofik; Jackson, Klarissa D; Salako, Omolola; Daramola, Adetola; Hall, Allison; Alatise, Olusegun; Ogun, Gabriel; Adeniyi, Adewale; Ayandipo, Omobolaji; Olajide, Thomas; Olasehinde, Olalekan; Arowolo, Olukayode; Adisa, Adewale; Afuwape, Oludolapo; Olusanya, Aralola; Adegoke, Aderemi; Tollefsbol, Trygve O; Arnett, Donna; Muehlbauer, Michael J; Newgard, Christopher B; Akinyemiju, Tomi.
Afiliación
  • Gupta A; Trinity College of Arts and Sciences, Duke University, Durham, NC, USA.
  • Saraiya V; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
  • Deveaux A; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
  • Oyekunle T; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
  • Jackson KD; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
  • Salako O; Divison of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC, USA.
  • Daramola A; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
  • Hall A; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
  • Alatise O; Department of Pathology, School of Medicine, Duke University, Durham, NC, USA.
  • Ogun G; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
  • Adeniyi A; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Ayandipo O; Federal Medical Center, Ogun State, Abeokuta, Nigeria.
  • Olajide T; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Olasehinde O; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
  • Arowolo O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
  • Adisa A; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
  • Afuwape O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
  • Olusanya A; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Adegoke A; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Tollefsbol TO; Our Lady of Apostle Catholic Hospital, Ibadan, Oyo State, Nigeria.
  • Arnett D; University of Alabama at Birmingham, Birmingham, AL, USA.
  • Muehlbauer MJ; College of Public Health, University of Kentucky, Lexington, KY, USA.
  • Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Sci Rep ; 12(1): 10631, 2022 06 23.
Article en En | MEDLINE | ID: mdl-35739205
There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers-total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides-with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias de la Mama Triple Negativas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias de la Mama Triple Negativas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido