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Survey of Anti-Pathogen Antibody Levels in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
O'Neal, Adam J; Glass, Katherine A; Emig, Christopher J; Vitug, Adela A; Henry, Steven J; Shungu, Dikoma C; Mao, Xiangling; Levine, Susan M; Hanson, Maureen R.
Afiliación
  • O'Neal AJ; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
  • Glass KA; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
  • Emig CJ; Augmenta Bioworks, Inc., Menlo Park, CA 94025, USA.
  • Vitug AA; Augmenta Bioworks, Inc., Menlo Park, CA 94025, USA.
  • Henry SJ; Augmenta Bioworks, Inc., Menlo Park, CA 94025, USA.
  • Shungu DC; Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA.
  • Mao X; Department of Radiology, Weill Cornell Medicine, New York, NY 10021, USA.
  • Levine SM; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
  • Hanson MR; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Proteomes ; 10(2)2022 Jun 13.
Article en En | MEDLINE | ID: mdl-35736801
Infectious pathogens are implicated in the etiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) because of the occurrence of outbreaks of the disease. While a number of different infectious agents have been associated with the onset of ME/CFS, the identity of a specific organism has been difficult to determine in individual cases. The aim of our study is to survey ME/CFS subjects for evidence of an infectious trigger and/or evidence of immune dysregulation via serological testing of plasma samples for antibodies to 122 different pathogen antigens. Immune profiles were compared to age-, sex-, and BMI-matched controls to provide a basis for comparison. Antibody levels to individual antigens surveyed in this study do not implicate any one of the pathogens in ME/CFS, nor do they rule out common pathogens that frequently infect the US population. However, our results revealed sex-based differences in steady-state humoral immunity, both within the ME/CFS cohort and when compared to trends seen in the healthy control cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proteomes Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proteomes Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza