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Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.
Jemth, Ann-Sofie; Scaletti, Emma Rose; Homan, Evert; Stenmark, Pål; Helleday, Thomas; Michel, Maurice.
Afiliación
  • Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. Electronic address: ann-sofie.jemth@ki.se.
  • Scaletti ER; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.
  • Homan E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Stenmark P; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.
  • Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden; Weston Park Cancer Centre, Department of Oncology & Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.
  • Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. Electronic address: maurice.michel@ki.se.
J Biol Chem ; 298(8): 102169, 2022 08.
Article en En | MEDLINE | ID: mdl-35732208
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Tratamiento Farmacológico de COVID-19 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Tratamiento Farmacológico de COVID-19 Límite: Humans Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos