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Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview.
Bogdanova, Maria; Zabirnyk, Arsenii; Malashicheva, Anna; Semenova, Daria; Kvitting, John-Peder Escobar; Kaljusto, Mari-Liis; Perez, Maria Del Mar; Kostareva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth J; Rutkovskiy, Arkady; Vaage, Jarle.
Afiliación
  • Bogdanova M; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Zabirnyk A; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Malashicheva A; Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
  • Semenova D; Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.
  • Kvitting JP; Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.
  • Kaljusto ML; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
  • Perez MDM; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
  • Kostareva A; Sanifit Therapeutics, Palma de Mallorca, Spain.
  • Stensløkken KO; Almazov National Medical Research Centre, Saint Petersburg, Russia.
  • Sullivan GJ; Department of Woman and Children Health, Karolinska Institute, Stockholm, Sweden.
  • Rutkovskiy A; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Vaage J; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Front Pharmacol ; 13: 835825, 2022.
Article en En | MEDLINE | ID: mdl-35721220
Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells. To develop non-surgical treatments, the molecular and cellular mechanisms of pathological calcification must be revealed. In the current overview, we present methods for evaluation of calcification in different ex vivo, in vitro and in vivo situations including imaging in patients. The latter include echocardiography, scanning with computed tomography and magnetic resonance imaging. Particular emphasis is on translational studies of calcific aortic valve stenosis with a special focus on cell culture using human primary cell cultures. Such models are widely used and suitable for screening of drugs against calcification. Animal models are presented, but there is no animal model that faithfully mimics human calcific aortic valve disease. A model of experimentally induced calcification in whole porcine aortic valve leaflets ex vivo is also included. Finally, miscellaneous methods and aspects of aortic valve calcification, such as, for instance, biomarkers are presented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza