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Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy.
Chang, Chia-Lin; Huang, Kevin Chih-Yang; Chen, Tsung-Wei; Chen, William Tzu-Liang; Huang, Hsuan-Hua; Liu, Ya-Ling; Kuo, Chia-Hui; Chao, K S Clifford; Ke, Tao-Wei; Chiang, Shu-Fen.
Afiliación
  • Chang CL; Department of Hematology and Oncology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C.
  • Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40402, Taiwan, R.O.C.
  • Chen TW; Translation Research Core, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C.
  • Chen WT; Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan, R.O.C.
  • Huang HH; Department of Pathology, Asia University Hospital, Asia University, Taichung 41354, Taiwan, R.O.C.
  • Liu YL; Department of Colorectal Surgery, Hsinchu China Medical University Hospital, Hsinchu 30272, Taiwan, R.O.C.
  • Kuo CH; School of Medicine, China Medical University, China Medical University, Taichung 40402, Taiwan, R.O.C.
  • Chao KSC; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C.
  • Ke TW; Department of Pathology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C.
  • Chiang SF; Laboratory of Precision Medicine, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C.
Oncol Lett ; 24(1): 238, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35720473
Rectal adenocarcinoma (READ) constitutes one-third of newly diagnosed colorectal cancer cases. Surgery, chemotherapy and concurrent chemoradiotherapy are the main treatments to improve patient outcomes for READ. However, patients with READ receiving these treatments eventually relapse, leading to a poor survival outcome. The present study collected surgical specimens from patients with READ and determined that cytoplasmic cell division cycle 27 (CDC27) expression was associated with the risk of lymph node metastasis and distant metastasis. Nuclear CDC27 expression was negatively associated with 5-year disease-free survival (DFS) and 5-year overall survival (OS) rates. Multivariate Cox proportional regression analysis showed that nuclear CDC27 was an independent prognostic factor in the patients with READ, especially in those treated with adjuvant chemotherapy. High nuclear CDC27 expression was significantly associated with poorer 5-year DFS (HR, 2.106; 95% CI, 1.275-3.570; P=0.003) and 5-year OS (HR, 2.369; 95% CI, 1.270-4.6810; P=0.005) rates. The data indicated that cytoplasmic CDC27 expression could affect tumor progression and that it plays an important role in metastasis. Nuclear CDC27 expression was markedly associated with poorer survival outcomes and was an independent prognostic factor in patients with postoperative adjuvant chemotherapy-treated READ. Thus, CDC27 expression serves as a potential prognostic marker for rectal tumor progression and chemotherapy treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Oncol Lett Año: 2022 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Oncol Lett Año: 2022 Tipo del documento: Article Pais de publicación: Grecia