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Compartmentalization and regulation of GTP in control of cellular phenotypes.
Wolff, David W; Bianchi-Smiraglia, Anna; Nikiforov, Mikhail A.
Afiliación
  • Wolff DW; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA. Electronic address: david.wolff@duke.edu.
  • Bianchi-Smiraglia A; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
  • Nikiforov MA; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: mikhail.nikiforov@duke.edu.
Trends Mol Med ; 28(9): 758-769, 2022 09.
Article en En | MEDLINE | ID: mdl-35718686
Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current Review, we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Guanosina Trifosfato Límite: Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Guanosina Trifosfato Límite: Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido