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Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.
Takwale, Akshay D; Kim, Eun Yeong; Jang, Yerin; Lee, Dong Ho; Kim, Seulgi; Choi, Yuri; Kim, Jin Hwan; Lee, Da Yeon; Kim, Yeongrin; Lee, So Myoung; Lee, Heung Kyoung; Nam, Hye Jin; Lee, Joo-Youn; Cho, Jin Hwa; Moon, Jeong Hee; Lee, Ga Seul; Kim, Jeong-Hoon; Kim, Pilho; Park, Chi Hoon; Hwang, Jong Yeon.
Afiliación
  • Takwale AD; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Kim EY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Jang Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Lee DH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Kim S; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Choi Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Kim JH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Lee DY; College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
  • Kim Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Lee SM; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Lee HK; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Nam HJ; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Lee JY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
  • Cho JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Moon JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
  • Lee GS; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28160, Republic of Korea.
  • Kim JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Department of Bioscience, University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Kim P; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
  • Park CH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: chpark@krict.re.kr.
  • Hwang JY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: jyhwang@krict.re.kr.
Bioorg Chem ; 127: 105923, 2022 10.
Article en En | MEDLINE | ID: mdl-35717803
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Adaptadoras Transductoras de Señales Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Adaptadoras Transductoras de Señales Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos