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Hematopoietic Cell Transplantation in the Treatment of Pediatric Acute Myelogenous Leukemia and Myelodysplastic Syndromes: Guidelines from the American Society of Transplantation and Cellular Therapy.
Tarlock, Katherine; Sulis, Maria Luisa; Chewning, Joseph H; Pollard, Jessica A; Cooper, Todd; Gamis, Alan; Shenoy, Shalini; Kutny, Matthew; Horan, John; Meshinchi, Soheil; Boelens, Jaap-Jan; Bleakley, Marie; Carpenter, Paul A; Kolb, E Anders.
Afiliación
  • Tarlock K; Seattle Children's Hospital, Division of Hematology/Oncology, and University of Washington Seattle, Washington; Fred Hutchinson Cancer Research Center, Clinical Research Division and University of Washington, Seattle, Washington. Electronic address: Katherine.tarlock@seattlechildrens.org.
  • Sulis ML; Department of Pediatric Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Chewning JH; Department of Pediatrics Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Pollard JA; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
  • Cooper T; Seattle Children's Hospital, Division of Hematology/Oncology, and University of Washington Seattle, Washington.
  • Gamis A; Division of Hematology/Oncology, Children's Mercy Hospital and Clinics, Kansas City, Missouri.
  • Shenoy S; Division of Pediatric Hematology/Oncology, Washington University in St. Louis, St. Louis, Missouri.
  • Kutny M; Department of Pediatrics Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Horan J; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
  • Meshinchi S; Fred Hutchinson Cancer Research Center, Clinical Research Division and University of Washington, Seattle, Washington.
  • Boelens JJ; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Bleakley M; Fred Hutchinson Cancer Research Center, Clinical Research Division and University of Washington, Seattle, Washington.
  • Carpenter PA; Fred Hutchinson Cancer Research Center, Clinical Research Division and University of Washington, Seattle, Washington.
  • Kolb EA; Nemours Center for Cancer and Blood Disorders, Alfred I. DuPont Hospital for Children, Wilmington, Delaware.
Transplant Cell Ther ; 28(9): 530-545, 2022 09.
Article en En | MEDLINE | ID: mdl-35717004
The role of allogeneic hematopoietic stem cell transplantation (HCT) in the treatment of acute myelogenous leukemia (AML) in children is reviewed and critically evaluated in this evidence-based review. Specific criteria were used for searching the published literature, grading the quality and strength of evidence, and assigning the strength of treatment recommendations. Genomic characterization and response to therapy have been critical in the risk stratification of pediatric AML. Although some children are cured with chemotherapy alone, allogeneic HCT offers a survival benefit in selected patients with certain unfavorable risk features and is the standard of care for children who relapse following initial treatment with chemotherapy. Important aspects of HCT include recipient characteristics, donor source, and preparative regimen. The goals of HCT are to reduce incidence of relapse, enhance graft-versus-leukemia (GVL) effects, and minimize graft-versus-host disease. Relapse following HCT remains a significant cause of treatment failure, and interventions pre- and post-HCT, especially those that may augment GVL, are an important focus of ongoing investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Guideline Límite: Child / Humans País/Región como asunto: America do norte Idioma: En Revista: Transplant Cell Ther Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Guideline Límite: Child / Humans País/Región como asunto: America do norte Idioma: En Revista: Transplant Cell Ther Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos