8-Methoxybutin inhibits &#945;-MSH induced melanogenesis and proliferation of skin melanoma by suppression of the transactivation activity of microphthalmia-associated transcription factor.

Oh, Eunji; Kim, Hyo Jin; Lee, Dohyun; Kang, Jeong Hwa; Kim, Hyung Geun; Han, Seung Hyun; Baek, Nam In; Kim, Kyong-Tai

8-Methoxybutin inhibits α-MSH induced melanogenesis and proliferation of skin melanoma by suppression of the transactivation activity of microphthalmia-associated transcription factor.

Oh, Eunji; Kim, Hyo Jin; Lee, Dohyun; Kang, Jeong Hwa; Kim, Hyung Geun; Han, Seung Hyun; Baek, Nam In; Kim, Kyong-Tai.

Afiliación

Oh E; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Kim HJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Lee D; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Kang JH; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Kim HG; Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin, South Korea.
Han SH; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Baek NI; Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin, South Korea.
Kim KT; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea. Electronic address: ktk@postech.ac.kr.

Biomed Pharmacother ; 152: 113272, 2022 Aug.

Article en En | MEDLINE | ID: mdl-35716437

Asunto(s)

Melanoma; Neoplasias Cutáneas; Animales; Línea Celular Tumoral; Proliferación Celular; Humanos; Melaninas/metabolismo; Melanocitos/metabolismo; Melanoma/tratamiento farmacológico; Melanoma/genética; Melanoma/metabolismo; Ratones; Factor de Transcripción Asociado a Microftalmía/metabolismo; Monofenol Monooxigenasa/metabolismo; Neoplasias Cutáneas/tratamiento farmacológico; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/metabolismo; Activación Transcripcional; alfa-MSH/metabolismo; alfa-MSH/farmacología; Melanoma Cutáneo Maligno

Palabras clave

8-methoxybutin; Anti-melanogenic effect; Flavonoid; MITF; Skin melanoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Francia

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