Electrochemically driven regioselective C-H phosphorylation of group 8 metallocenes.

Zheng, Hao; Liu, Chang-Hui; Guo, Shi-Yu; He, Gu-Cheng; Min, Xiang-Ting; Zhou, Bo-Chao; Ji, Ding-Wei; Hu, Yan-Cheng; Chen, Qing-An

Zheng, Hao; Liu, Chang-Hui; Guo, Shi-Yu; He, Gu-Cheng; Min, Xiang-Ting; Zhou, Bo-Chao; Ji, Ding-Wei; Hu, Yan-Cheng; Chen, Qing-An.

Afiliación

Zheng H; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Liu CH; University of Chinese Academy of Sciences, Beijing, 100049, China.
Guo SY; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
He GC; University of Chinese Academy of Sciences, Beijing, 100049, China.
Min XT; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Zhou BC; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Ji DW; University of Chinese Academy of Sciences, Beijing, 100049, China.
Hu YC; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Chen QA; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

Nat Commun ; 13(1): 3496, 2022 Jun 17.

Article en En | MEDLINE | ID: mdl-35715392

RESUMEN

Metallocenes are privileged backbones for synthesis and catalysis. However, the direct dehydrogenative C-H functionalization of unsymmetric metallocenes suffers from reactivity and selectivity issues. Herein, we report an electrochemically driven regioselective C-H phosphorylation of group 8 metallocenes. Mechanistic investigations indicate this dehydrogenative cross coupling occurs through an electrophilic radical substitution of the metallocene with a phosphoryl radical, facilitated by the metallocene itself. This work not only offers an efficient and divergent synthesis of phosphorylated metallocenes, but also provides a guide to interpret the reactivity and regioselectivity for the C-H functionalization of unsymmetric metallocenes.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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