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Effects of polyethylene glycol-20k IV solution on donor management in a canine model of donor brain death.
Kang, Hae Sung; Wickramaratne, Niluka; Liebrecht, Loren K; Mangino, Martin J.
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  • Kang HS; Departments of Surgery Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
  • Wickramaratne N; Departments of Surgery Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
  • Liebrecht LK; Departments of Surgery Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
  • Mangino MJ; Departments of Surgery Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA; Emergency Medicine Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA; Physiology and Biophysics Virginia Commonwealth University, School of Medicine, Richmond, VA 23298,
Biomed Pharmacother ; 152: 113293, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35714513
BACKGROUND: Traditionally, vasopressors and crystalloids have been used to stabilize brain dead donors; however, the use of crystalloid is fraught with complications. This study aimed to investigate the effectiveness of a newly developed impermeant solution, polyethylene glycol-20k IV solution (PEG-20k) for resuscitation and support of brain dead organ donors. METHODS: Brain death was induced in adult beagle dogs and a set volume of PEG-20k or crystalloid solution was given thereafter. The animals were then resuscitated over 16 h with vasopressors and crystalloid as necessary to maintain mean arterial pressure of 80-100 mmHg. The kidneys were procured and cold-stored for 24 h, after which they were analyzed using the isolated perfused kidney model. RESULTS: The study group required significantly less crystalloid volume and vasopressors while having less urine output and requiring less potassium supplementation than the control group. Though the two groups' mean arterial pressure and lactate levels were comparable, the study group's kidneys showed less preservation injury after short-term reperfusion indexed by decreased lactate dehydrogenase release and higher creatinine clearance than the control group. CONCLUSIONS: The use of polyethylene glycol-20k IV solution for resuscitating brain dead donors decreases cell swelling and improves intravascular volume, thereby improving end organ oxygen delivery before procurement and so preventing ischemia-reperfusion injury after transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Muerte Encefálica Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Muerte Encefálica Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia