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The effect of COVID-19 lockdown on mental health, gut microbiota composition and serum cortisol levels.
Sik Novak, Karin; Bogataj Jontez, Nives; Kenig, Sasa; Hladnik, Matjaz; Baruca Arbeiter, Alenka; Bandelj, Dunja; Cernelic Bizjak, Masa; Petelin, Ana; Mohorko, Nina; Jenko Praznikar, Zala.
Afiliación
  • Sik Novak K; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Bogataj Jontez N; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Kenig S; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Hladnik M; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia.
  • Baruca Arbeiter A; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia.
  • Bandelj D; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia.
  • Cernelic Bizjak M; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Petelin A; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Mohorko N; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
  • Jenko Praznikar Z; Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
Stress ; 25(1): 246-257, 2022 01.
Article en En | MEDLINE | ID: mdl-35713539
The aim of this study was to assess changes in mental health, gut microbiota composition, and stress marker serum cortisol due to COVID-19 lockdown in asymptomatic individuals. Healthy adults participated in anthropometric measurements, blood and stool sample collection pre-lockdown and post-lockdown (n = 38, 63.2% females), lifestyle and psychological questionnaires were included in pre-lockdown measurement and lockdown survey (n = 46, 67.4% females). Subjects reported significantly higher body dissatisfaction (p = 0.007) and anxiety (p = 0.002), and significantly lower positive affect (p = 0.001) during lockdown compared with pre-lockdown. According to perceived stress, 51.6% of females and 20% of males experienced moderate to high stress. This was reflected in serum cortisol levels that significantly increased only in females (p = 0.006) post-lockdown and correlated with perceived stress (p = 0.037) and anxiety (p = 0.031). In addition to psychological measures, changes in gut microbiota composition were observed. Gut microbial alpha diversity significantly decreased (p = 0.033), whereas relative abundance of Proteobacteria significantly increased (p = 0.043) post-lockdown. Depression during lockdown was moderately positively correlated with changes in Bacteroidetes abundance (p = 0.015) and negatively with changes in Firmicutes abundance (p = 0.008). Alistipes abundance post-lockdown was moderately positively correlated with anxiety (p = 0.004) and negative affect (p = 0.005) during lockdown. Despite a small sample size and not being able to perform objective measurements during lockdown, the results confirm the effect of lockdown on mental health and gut microbiota composition that could have a great impact on our health (ClinicalTrials identifier: NCT04347213).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / COVID-19 Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / COVID-19 Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Reino Unido