Inhibitory effects of saeu-jeot extract on NLRP3 inflammasome activation and radiation-induced micronucleus formation.
Food Sci Nutr
; 10(6): 1921-1927, 2022 Jun.
Article
en En
| MEDLINE
| ID: mdl-35702305
Purpose: Saeu-jeot, or shrimp paste, is a traditional Korean high-salt fermented seafood. This study elucidated the effects of saeu-jeot extract (SJE) on NLRP3 inflammasome activation and radiation-induced micronucleus formation. Method: We treated lipopolysaccharide-primed mouse bone marrow-derived macrophages with the NLRP3 inflammasome activators ATP and nigericin. We also analyzed the acute effects of ionizing radiation on micronucleated polychromatic erythrocytes (MnPCEs) in whole-body gamma-irradiated male BALB/c and C57BL/6 mice after oral administration of SJE. Results: SJE significantly inhibited NLRP3 inflammasome activation, reducing IL-1ß secretion in vitro. In addition, the frequency of MnPCEs was significantly lower in SJE-treated mice. Conclusions: SJE has anti-inflammatory effects and reduces radiation-induced chromosome damage. Advance in knowledge: There are no reports concerning the effects of SJE on NLRP3 inflammasome activation or radioprotection. This experiment showed the radioprotective effects of saeu-jeot.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Food Sci Nutr
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Estados Unidos