Your browser doesn't support javascript.
loading
Impact of severe obesity in the management of patients with high-risk endometrial cancer: A FRANCOGYN study.
Simon, Ombline; Dion, Ludivine; Nyangoh Timoh, Krystel; Dupré, Pierre François; Azaïs, Henri; Bendifallah, Sofiane; Touboul, Cyril; Dabi, Yohan; Graesslin, Olivier; Raimond, Emilie; Costaz, Hélène; Kerbage, Yohan; Huchon, Cyrille; Mimoun, Camille; Koskas, Martin; Akladios, Cherif; Lecointre, Lise; Canlorbe, Geoffroy; Chauvet, Pauline; Ouldamer, Lobna; Levêque, Jean; Lavoué, Vincent.
Afiliación
  • Simon O; Gynecology Department of Rennes Teaching Hospital, Service de Gynécologie du CHU de Rennes, Hôpital sud 16 Bd de Bulgarie, Rennes 35000, France.
  • Dion L; Gynecology Department of Rennes Teaching Hospital, Service de Gynécologie du CHU de Rennes, Hôpital sud 16 Bd de Bulgarie, Rennes 35000, France.
  • Nyangoh Timoh K; Gynecology Department of Rennes Teaching Hospital, Service de Gynécologie du CHU de Rennes, Hôpital sud 16 Bd de Bulgarie, Rennes 35000, France.
  • Dupré PF; Gynecology department of Brest Teaching Hospital, France.
  • Azaïs H; Gynecology department of Georges Pompidou European Teaching Hospital, AP-HP, France.
  • Bendifallah S; Gynecology department of Tenon Teaching Hospital, AP-HP, France.
  • Touboul C; Gynecology department of Tenon Teaching Hospital, AP-HP, France.
  • Dabi Y; Gynecology department of Tenon Teaching Hospital, AP-HP, France.
  • Graesslin O; Gynecology department of Reims Teaching Hospital, AP-HP, France.
  • Raimond E; Gynecology department of Reims Teaching Hospital, AP-HP, France.
  • Costaz H; Comprehensive Cancer Center of Dijon, France.
  • Kerbage Y; Gynecology department of Lille Teaching Hospital, France.
  • Huchon C; Gynecology department of Lariboisiere Teaching Hospital, AP-HP, France.
  • Mimoun C; Gynecology department of Lariboisiere Teaching Hospital, AP-HP, France.
  • Koskas M; Gynecology department of Bichat Teaching Hospital, AP-HP, France.
  • Akladios C; Gynecology department of Strasbourg Teaching Hospital, France.
  • Lecointre L; Gynecology department of Strasbourg Teaching Hospital, France.
  • Canlorbe G; Gynecology department of La Pitié Salpétrière Teaching Hospital, AP-HP, France.
  • Chauvet P; Gynecology department of Clermont Ferrand Teaching Hospital, AP-HP, France.
  • Ouldamer L; Gynecology department of Tours Teaching Hospital, AP-HP, France.
  • Levêque J; Gynecology Department of Rennes Teaching Hospital, Service de Gynécologie du CHU de Rennes, Hôpital sud 16 Bd de Bulgarie, Rennes 35000, France.
  • Lavoué V; Gynecology Department of Rennes Teaching Hospital, Service de Gynécologie du CHU de Rennes, Hôpital sud 16 Bd de Bulgarie, Rennes 35000, France. Electronic address: Vincent.lavoue@chu-rennes.fr.
J Gynecol Obstet Hum Reprod ; 51(7): 102429, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35700933
OBJECTIVE: To assess the surgical management and survival of severely obese patients with high-risk endometrial cancer. MATERIALS AND METHODS: Data from 269 patients with high-risk endometrial cancer who were treated between 2001 and 2018 were collected from a multicenter database (11 centers). We classified the patients according to their BMI and compared outcomes in two groups: a normal weight group of women with a BMI < 25 kg/m2, and a severe obesity group of women with a BMI ≥ 35 kg/m2. The groups were compared for epidemiologic, pathologic, management, relapse-free survival (RFS) and overall survival (OS) elements. RESULTS: Patients in the severe obesity group were younger (64 years vs. 68 years, p < 0.05) and had more comorbidities (hypertension, diabetes). They also had more locally advanced tumors and pelvic lymph node involvement (47% vs 24%, p < 0.05). The severely obese patients were less likely to undergo recommended surgical staging, with fewer lumbar aortic dissections than women of normal weight (23% vs 36%, p < 0.05) and fewer pelvic sentinel lymph node biopsies (26.5% vs 12.1%, p < 0.05). No difference in RFS or OS were observed between the two groups. CONCLUSION: Patients with severe obesity and high-risk endometrial cancer have more locally advanced tumors, and are less likely to be managed according to surgical recommendations. However, RFS and OS do not seem to be affected.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Neoplasias Endometriales Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Neoplasias Endometriales Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia