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Buffet-style Cu(II) for enhance disulfiram-based cancer therapy.
Zhao, Liping; Wang, Xiaoxia; Lou, Han; Jiang, Mingxia; Wu, Xinghan; Qin, Jiamin; Zhang, Jingqi; Guan, Xiuwen; Li, Wentong; Zhang, Weifen; Ma, Jinlong.
Afiliación
  • Zhao L; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
  • Wang X; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
  • Lou H; School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China.
  • Jiang M; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
  • Wu X; Department of Pathology, Weifang Medical University, Weifang, China.
  • Qin J; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
  • Zhang J; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
  • Guan X; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China; Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, Shandong, China; Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang M
  • Li W; Department of Pathology, Weifang Medical University, Weifang, China.
  • Zhang W; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China; Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, Shandong, China; Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang M
  • Ma J; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China; Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, Shandong, China; Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang M
J Colloid Interface Sci ; 624: 734-746, 2022 Oct 15.
Article en En | MEDLINE | ID: mdl-35696791
Studies have shown that disulfiram (DSF) can combine with Cu2+ to form bis(N, N-diethyldithiocarbamate) copper(II) complex (CuET) as antitumor drugs. However, there is insufficient endogenous Cu2+ dose to eradicate cancer cells selectively. Inspired by the buffet, we use Cu2+ doped hollow zeolitic imidazolate framework nanoparticles (HZIFCu) as the carrier and equipped with DSF and indocyanine green (ICG) and targeted by folic acid (FA) (D&I@HZIFCu-FA) to enhance DSF-based cancer therapy. D&I@HZIFCu-FA could effectively supply Cu2+ by a buffet-style, assisting the "DSF-to-CuET" transformation in the tumor. Additionally, self-supply Cu2+ could convert H2O2 into ·OH by triggering a Fenton-like reaction for chemo-dynamic therapy, and ICG achieves photothermal therapy for tumors under laser irradiation. This work provides a buffet-style for Cu2+ to make DSF a strong candidate for cancer treatment by combining chemotherapy, chemo-dynamic therapy, and photothermal therapy and inspires more research about its applications in tumor therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Idioma: En Revista: J Colloid Interface Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Idioma: En Revista: J Colloid Interface Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos