Your browser doesn't support javascript.
loading
Experimental model of periodontitis and rheumatoid arthritis potentiates the deleterious effects on functional capacity, leukocyte migration, synovial and periodontal tissues in Wistar rats.
Schnaufer, Thaís Caroline; Tavares, Alana Ludemila; Hoss, Iranilda Moha; Correia, Bruna Rafaela; Pradal, Lilian de Araújo; Piana, Ediana Amanda; Wachter, Franciane; Stein, Taciane; Ayala, Thais Soprani; Menolli, Rafael Andrade; Bertolini, Gladson Ricardo Flor; Meire Costa, Rose; Ribeiro, Lucinéia de Fátima Chasko; Nassar, Carlos Augusto; Nassar, Patrícia Oehlmeyer.
Afiliación
  • Schnaufer TC; Master's of Science in Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Tavares AL; Master's of Science in Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Hoss IM; Master's of Science in Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Correia BR; Master's of Science in Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Pradal LA; Master's of Science in Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Piana EA; Department of Periodontology, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Wachter F; Department of Periodontology, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Stein T; Health and Bioscences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Ayala TS; Center of Medical and Pharmaceutical Sciences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Menolli RA; Center of Medical and Pharmaceutical Sciences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Bertolini GRF; Center of Biological and Health Sciences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Meire Costa R; Center of Biological and Health Sciences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Ribeiro LFC; Center of Biological and Health Sciences, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Nassar CA; Department of Periodontology, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
  • Nassar PO; Department of Periodontology, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
Acta Odontol Scand ; 81(1): 40-49, 2023 Jan.
Article en En | MEDLINE | ID: mdl-35694780
OBJECTIVE: This study aimed to evaluate whether ligature-induced periodontitis and rheumatoid arthritis (RA) potentiate the deleterious effects on functional capacity, periodontal and synovial tissues, leukocyte migration, and interleukin 17 (IL-17) levels, and to investigate the repercussions of single Freund's Complete Adjuvant (FCA) injection associated with periodontitis. MATERIALS AND METHODS: Fifty-one male Wistar rats were randomised into six groups: control (CG, n = 8), RA (RAG, n = 9), periodontitis (PG, n = 9), periodontitis and RA (PRAG, n = 9), periodontitis and intradermal injection (PIDG, n = 9), and periodontitis and intra-articular injection (PIAG, n = 7). The animals underwent ligature placement and one or two injections with FCA to induce RA. Motor disability, nociceptive threshold, joint edema, and muscle strength were assessed, and the animals were euthanized on day 30. Synovial fluid, hemimandibles, and knee joints were collected. RESULTS: PRAG showed no reduction of edema or improvement of muscle strength, whereas it showed most significant changes in leukocyte migration, morphological analyses of the synovial membrane (SM), and radiographic and histometric analyses of the jaw. The PIAG showed some alterations, though not permanent. CONCLUSION: Ligature-induced periodontitis and RA induced by two FCA injections accentuated the deleterious effects on functional capacity, leukocyte migration, synovial and periodontal tissues.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Artritis Reumatoide Tipo de estudio: Clinical_trials Límite: Animals Idioma: En Revista: Acta Odontol Scand Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Artritis Reumatoide Tipo de estudio: Clinical_trials Límite: Animals Idioma: En Revista: Acta Odontol Scand Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido