Association of maternal pre-pregnancy body mass index with birth weight and preterm birth among singletons conceived after frozen-thawed embryo transfer.

Lin, Jiaying; Guo, Haiyan; Wang, Bian; Zhu, Qianqian

Lin, Jiaying; Guo, Haiyan; Wang, Bian; Zhu, Qianqian.

Afiliación

Lin J; Department of Assisted Reproduction, Shanghai Ninth People's Hospital affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, China.
Guo H; Department of Assisted Reproduction, Shanghai Ninth People's Hospital affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, China.
Wang B; Department of Assisted Reproduction, Shanghai Ninth People's Hospital affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, China.
Zhu Q; Department of Assisted Reproduction, Shanghai Ninth People's Hospital affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, China. qianqianzhu1988@126.com.

Reprod Biol Endocrinol ; 20(1): 86, 2022 Jun 10.

Article en En | MEDLINE | ID: mdl-35689242

RESUMEN

BACKGROUND: To explore the effect of pre-pregnancy body mass index (BMI) on neonatal outcomes among singletons born after frozen embryo transfer (FET). METHODS: This large retrospective cohort study included 18,683 singleton infants born after FET during the period from Jan 1, 2007 to Dec 31, 2019. The main outcomes were large for gestational age (LGA) and preterm birth. Logistic regression models with generalized estimating equations for clustering by patients to estimate odds ratios of LGA and preterm birth. RESULTS: Overweight was positively associated with LGA overall (adjusted OR 1.78 [95%CI 1.60-1.98]), and this association was consistent across age categories. The underweight was inversely associated with LGA among mothers younger than 35 years (adjusted OR 0.49 [95%CI 0.39-0.62] among mothers younger than 30 years; adjusted OR 0.47 [95%CI 0.37-0.60] among mothers aged 30-34 years), but this association was no significant among mothers 35 years or older. Overweight was positively and significantly associated with preterm birth overall (adjusted OR 1.52 [95%CI 1.30-1.77]) and consistently across age categories. The underweight mothers younger than 30 years had a decreased risk of preterm birth (adjusted OR 0.70 [95%CI 0.51-0.97]), but the underweight was no significantly associated with preterm birth among women aged 30 years of older. CONCLUSIONS: The risks of LGA and preterm birth were increased in singletons born to overweight mothers, regardless of the maternal age. Underweight decreased the risk of LGA and preterm birth for younger mothers. These findings are important for providing preconceptional counseling to specifically targeted women at high risk of LGA and preterm birth.

Asunto(s)

Nacimiento Prematuro; Peso al Nacer; Índice de Masa Corporal; Transferencia de Embrión; Femenino; Humanos; Lactante; Recién Nacido; Sobrepeso/epidemiología; Embarazo; Nacimiento Prematuro/epidemiología; Estudios Retrospectivos; Delgadez/epidemiología

Palabras clave

Body mass index; Frozen embryo transfer; Large for gestational age; Preterm birth

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Reprod Biol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA REPRODUTIVA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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