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Siamoside A: a new C-glycosylated flavone from Senna siamea (Lam.) H. S. Irwin & Barneby (Caesalpiniaceae).
Chedjou, Isaac Nde; Ngouafong, Francis Tatong; Tchuenguem, Roland Tchuenteu; Dzoyem, Jean Paul; Ponou, Beaudelaire Kemvoufo; Teponno, Rémy Bertrand; Barboni, Luciano; Tapondjou, Léon Azefack.
Afiliación
  • Chedjou IN; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Ngouafong FT; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Tchuenguem RT; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Dzoyem JP; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Ponou BK; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Teponno RB; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Barboni L; School of Science and Technology, Chemistry Division, University of Camerino, CHIP - CHemistry Interdisciplinary Project, Camerino, Italy.
  • Tapondjou LA; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Nat Prod Res ; 37(20): 3461-3469, 2023.
Article en En | MEDLINE | ID: mdl-35687822
Phytochemical investigation of the methanol extracts from the leaves and bark of Senna siamea resulted in the isolation of one new flavone C-glycoside: apigenin-8-C-[6''-(E)-feruloyl]-ß-D-glucopyranoside] (1), together with sixteen known compounds including quercetin-3-O-α-L-rhamnoside (2), vitexin (3), isovitexin (4), quercetin-3-O-ß-D-glucopyranoside (5), quercetin-3-O-ß-D-arabinopyranoside (6), quercetin (7), kaempferol (8), methyl inositol (9), sucrose (10), betulinic acid (11), vanillic acid (12), stigmastane-3ß,6α-diol (13), aurantiamide acetate (14), robinetinidol (15), catechin (16) and epicatechin (17). The structures of these compounds were established on the basis of their spectroscopic (1 D and 2 D NMR) and mass spectrometric (ESI-TOF-MS) data. The methanol extracts, fractions and some of the isolated compounds were screened for their antimicrobial properties against five microbial strains. The methanol extract and the ethyl acetate fraction from the bark showed very weak antifungal activity against C. glabrata with the same MIC value of 128 µg/mL. Compound 7 was weakly active against C. albicans with MIC of 32 µg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido