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Injectable and Self-Healing Polysaccharide Hydrogel Loading Molybdenum Disulfide Nanoflakes for Synergistic Photothermal-Photodynamic Therapy of Breast Cancer.
Qi, Yujie; Yuan, Yifeng; Qian, Zhiyi; Ma, Xiaodie; Yuan, Weizhong; Song, Ye.
Afiliación
  • Qi Y; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
  • Yuan Y; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
  • Qian Z; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
  • Ma X; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
  • Yuan W; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
  • Song Y; Department of Ultrasongraphy, The affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, P. R. China.
Macromol Biosci ; 22(9): e2200161, 2022 09.
Article en En | MEDLINE | ID: mdl-35676757
In order to overcome the limitation of traditional therapies for cancer and improve the accuracy of treatment, more advantageous cancer treatment methods need to be explored and studied. As a result, photothermal photodynamic therapy of breast cancer using bovine serum albumin (BSA) modifies molybdenum disulfide nanoflakes. Then the well-dispersed BSA-MoS2 NFs are loaded in the injectable and self-healing polysaccharide hydrogel which is prepared by the reaction of oxidized sodium alginate (OSA) and hydroxypropyl chitosan (HPCS) through the formation of Schiff base bonds. The injection and self-healing properties of the nanocomposite hydrogel are investigated. In vitro photothermal and photodynamic investigations demonstrate that BSA-MoS2 NFs possess obvious photothermal conversion and production of reactive oxygen species (ROS) under the irradiation of near infrared (NIR) laser (808 nm). In vivo anticancer investigation indicates that the nanocomposite hydrogel can be directly injected and remain in the tumor sites and achieve the synergistic photothermal-photodynamic therapy of cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Neoplasias Límite: Humans Idioma: En Revista: Macromol Biosci Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Neoplasias Límite: Humans Idioma: En Revista: Macromol Biosci Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Alemania