Your browser doesn't support javascript.
loading
Neural network learning defines glioblastoma features to be of neural crest perivascular or radial glia lineages.
Hu, Yizhou; Jiang, Yiwen; Behnan, Jinan; Ribeiro, Mariana Messias; Kalantzi, Chrysoula; Zhang, Ming-Dong; Lou, Daohua; Häring, Martin; Sharma, Nilesh; Okawa, Satoshi; Del Sol, Antonio; Adameyko, Igor; Svensson, Mikael; Persson, Oscar; Ernfors, Patrik.
Afiliación
  • Hu Y; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Jiang Y; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Behnan J; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Ribeiro MM; Computational Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.
  • Kalantzi C; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Zhang MD; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Lou D; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Häring M; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Sharma N; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Okawa S; Computational Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.
  • Del Sol A; Computational Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg.
  • Adameyko I; CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain.
  • Svensson M; IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.
  • Persson O; Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, Vienna, Austria.
  • Ernfors P; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Sci Adv ; 8(23): eabm6340, 2022 Jun 10.
Article en En | MEDLINE | ID: mdl-35675414
Glioblastoma is believed to originate from nervous system cells; however, a putative origin from vessel-associated progenitor cells has not been considered. We deeply single-cell RNA-sequenced glioblastoma progenitor cells of 18 patients and integrated 710 bulk tumors and 73,495 glioma single cells of 100 patients to determine the relation of glioblastoma cells to normal brain cell types. A novel neural network-based projection of the developmental trajectory of normal brain cells uncovered two principal cell-lineage features of glioblastoma, neural crest perivascular and radial glia, carrying defining methylation patterns and survival differences. Consistently, introducing tumorigenic alterations in naïve human brain perivascular cells resulted in brain tumors. Thus, our results suggest that glioblastoma can arise from the brains' vasculature, and patients with such glioblastoma have a significantly poorer outcome.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos