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Genoprotective effect of cornelian cherry (Cornus mas L.) phytochemicals, electrochemical and ab initio interaction study.
Szczepaniak, Oskar; Ligaj, Marta; Stuper-Szablewska, Kinga; Kobus-Cisowska, Joanna.
Afiliación
  • Szczepaniak O; Department of Gastronomy Sciences and Functional Foods, Poznan University of Life Sciences, Poland. Electronic address: oskar.szczepaniak@up.poznan.pl.
  • Ligaj M; Department of Non-Food Products Quality and Packaging Development, Poznan University of Economics and Business, Poland.
  • Stuper-Szablewska K; Department of Chemistry, Poznan University of Life Sciences, Poland.
  • Kobus-Cisowska J; Department of Gastronomy Sciences and Functional Foods, Poznan University of Life Sciences, Poland.
Biomed Pharmacother ; 152: 113216, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35665669
Cornelian cherry (Cornus mas L.) has broad and multidimensional potential in preventing civilisational diseases. Part of these diseases results from DNA oxidative mutations. Thus, the paper aimed to predict how phenolics present in C. mas may interact with dsDNA in ab initio experiment and to check the effect of different cornelian cherry extracts on DNA structure and DNA oxidation. A special research model was designed using biosensor with a carbonpaste electrode. We resulted in various effects observed for phenolics and the extracts. Flavonoids, but of vitexin interacted with declining energy of the DNA models and liability of DNA oxidation. However, for 8-oxoguaniosine the trend was the opposite. Among the evaluated extracts, water-ethanolic extracts caused decline in adenine and guanine signals after dsDNA exposition on the extract. Principal component analysis showed that alcoholic extracts of cv. Szafer and Slowianin, which were rich in apigenin and kaempferol exhibit mild genoprotective effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cornus Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cornus Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article Pais de publicación: Francia