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Differences in gene expression despite identical histomorphology in sinonasal intestinal-type adenocarcinoma and metastases from colorectal adenocarcinoma.
Sjöstedt, Sannia; Vieira, Filipe Garrett; Karnov, Kirstine; Agander, Tina Klitmøller; Willemoe, Gro Linno; Rohrberg, Kristoffer Staal; Nielsen, Finn Cilius; von Buchwald, Christian.
Afiliación
  • Sjöstedt S; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Vieira FG; Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Karnov K; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Agander TK; Department of Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
  • Willemoe GL; Department of Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
  • Rohrberg KS; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Nielsen FC; Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
  • von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.
APMIS ; 130(9): 551-559, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35662259
Sinonasal intestinal-type adenocarcinoma (sITAC) is histomorphologically indistinguishable from colorectal adenocarcinoma (CRC) leading to diagnostic challenges. Metastases from CRCs to the sinonasal tract have been reported. The aim of the study was to identify a biomarker making it possible to distinguish between sITAC and metastases of colorectal origin. Formalin-fixated paraffin-embedded (FFPE) tissue from 20 consecutive patients with sITAC treated at Rigshospitalet, Denmark from 2005 to 2017, 20 patients with CRC, and second patients with both sinonasal and colorectal carcinomas were included, and RNA-sequencing was performed on all samples. Moreover, a series of 26 samples from metastasizing CRC were included (in-house data). 3139 differentially expressed genes were identified, of these several were deemed as possible biomarkers, including CSDE1, for which immunohistochemical staining was performed. sITAC and CRC differ in genomic expression. CSDE1, previously found upregulated in CRC, was significantly differentially expressed. Using immunohistochemical staining, no sITACs displayed strong and diffuse staining for CSDE1, which represents a potential marker to use in distinguishing sITAC from a metastasis of colorectal origin. This knowledge could improve the diagnostic process and hopefully the outcome in patients with this rare tumor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenocarcinoma Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenocarcinoma Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Dinamarca