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Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19.
Silva, Mauro G; Corradi, Gerardo R; Pérez Duhalde, Juan I; Nuñez, Myriam; Cela, Eliana M; Gonzales Maglio, Daniel H; Brizzio, Ana; Salazar, Martin R; Espeche, Walter G; Gironacci, Mariela M.
Afiliación
  • Silva MG; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina.
  • Corradi GR; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina.
  • Pérez Duhalde JI; Unidad de Enfermedades Cardiometabólicas, Hospital San Martín de La Plata, La Plata, Argentina.
  • Nuñez M; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Matemáticas, Buenos Aires, Argentina.
  • Cela EM; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Inmunología-IDEHU, Buenos Aires, Argentina.
  • Gonzales Maglio DH; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Inmunología-IDEHU, Buenos Aires, Argentina.
  • Brizzio A; Unidad de Enfermedades Cardiometabólicas, Hospital San Martín de La Plata, La Plata, Argentina.
  • Salazar MR; Unidad de Enfermedades Cardiometabólicas, Hospital San Martín de La Plata, La Plata, Argentina.
  • Espeche WG; Unidad de Enfermedades Cardiometabólicas, Hospital San Martín de La Plata, La Plata, Argentina.
  • Gironacci MM; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina. Electronic address: mariela@qb.ffyb.uba.ar.
Biomed Pharmacother ; 152: 113201, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35661534
BACKGROUND: Besides its counterbalancing role of the renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE) 2 is the receptor for the type 2 coronavirus that causes severe acute respiratory syndrome, the etiological agent of COVID-19. COVID-19 is associated with increased plasmatic ACE2 levels, although conflicting results have been reported regarding angiotensin (Ang) II and Ang-(1-7) levels. We investigated plasmatic ACE2 protein levels and enzymatic activity and Ang II and Ang-(1-7) levels in normotensive and hypertensive patients hospitalized with COVID-19 compared to healthy subjects. METHODS: Ang II and Ang-(1-7), and ACE2 activity and protein levels were measured in 93 adults (58 % (n = 54) normotensive and 42 % (n = 39) hypertensive) hospitalized with COVID-19. Healthy, normotensive (n = 33) and hypertensive (n = 7) outpatient adults comprised the control group. RESULTS: COVID-19 patients displayed higher ACE2 enzymatic activity and protein levels than healthy subjects. Within the COVID-19 group, ACE2 activity and protein levels were not different between normotensive and hypertensive-treated patients, not even between COVID-19 hypertensive patients under RAS blockade treatment and those treated with other antihypertensive medications. Ang II and Ang-(1-7) levels significantly decreased in COVID-19 patients. When COVID-19 patients under RAS blockade treatment were excluded from the analysis, ACE2 activity and protein levels remained higher and Ang II and Ang-(1-7) levels lower in COVID-19 patients compared to healthy people. CONCLUSIONS: Our results support the involvement of RAS in COVID-19, even when patients under RAS blockade treatment were excluded. The increased circulating ACE2 suggest higher ACE2 expression and shedding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Hipertensión Límite: Adult / Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Francia
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Hipertensión Límite: Adult / Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Francia