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FDG-PET/CT-guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma.
Rajamäki, Aino; Kuitunen, Hanne; Sorigue, Marc; Kokkonen, Salla-Maarit; Kuittinen, Outi; Sunela, Kaisa.
Afiliación
  • Rajamäki A; Department of Oncology, Hospital Nova of Central Finland, Jyväskylä, Finland.
  • Kuitunen H; Institute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland.
  • Sorigue M; Department of Oncology, Oulu University Hospital, Oulu, Finland.
  • Kokkonen SM; Department of Hematology, ICO-Hospital Germans Trias i Pujol, Functional cytomics-IJC, Badalona, Spain.
  • Kuittinen O; Department of Nuclear Medicine, Oulu University Hospital, Oulu, Finland.
  • Sunela K; Institute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland.
Cancer Med ; 12(1): 407-411, 2023 01.
Article en En | MEDLINE | ID: mdl-35661431
AIM: The purpose of the study was to evaluate the clinical impact of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). METHODS: This retrospective study included all the patients who had undergone FDG-PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. RESULTS: The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG-PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified HT had no previous clinical suspicion of transformation. CONCLUSION: Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG-PET/CT is valuable in detecting clinically unsuspected HT of FL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Folicular / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Folicular / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos