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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.
Hashem, Sheema; Ali, Tayyiba Akbar; Akhtar, Sabah; Nisar, Sabah; Sageena, Geetanjali; Ali, Shahid; Al-Mannai, Sharefa; Therachiyil, Lubna; Mir, Rashid; Elfaki, Imadeldin; Mir, Mohammad Muzaffar; Jamal, Farrukh; Masoodi, Tariq; Uddin, Shahab; Singh, Mayank; Haris, Mohammad; Macha, Muzafar; Bhat, Ajaz A.
Afiliación
  • Hashem S; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar.
  • Ali TA; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar.
  • Akhtar S; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar.
  • Nisar S; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar.
  • Sageena G; Keshav Mahavidyalaya, University of Delhi, New Delhi 110034, India.
  • Ali S; International Potato Center (CIP), Shillong, Meghalaya, India.
  • Al-Mannai S; Division of Translational Medicine, Research Branch, Sidra Medicine, Doha 26999, Qatar.
  • Therachiyil L; Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; Department of Pharmaceutical Sciences, College of Pharmacy, Qatar University, Doha, Qatar.
  • Mir R; Prince Fahd Bin Sultan Research chair, Department Of Medical Lab Technology, FAMS, University of Tabuk,Saudi Arabia.
  • Elfaki I; Department of Biochemistry, University of Tabuk, Tabuk, Saudi Arabia.
  • Mir MM; Department of Basic Medical Sciences, College of Medicine, University of Bisha, Saudi Arabia.
  • Jamal F; Dr. Rammanohar Lohia Avadh University, Ayodhya, India.
  • Masoodi T; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar.
  • Uddin S; Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
  • Singh M; Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Haris M; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar; Laboratory Animal Research Center, Qatar University, Doha 2713, Qatar; Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Phil
  • Macha M; Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Kashmir, India. Electronic address: muzafar.macha@islamicuniversity.edu.in.
  • Bhat AA; Laboratory of Molecular and Metabolic Imaging, Sidra Medicine, Doha, Qatar. Electronic address: abhat@sidra.org.
Biomed Pharmacother ; 150: 113054, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35658225
Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as anticancer agents is an acceptable therapeutic approach due to accessibility, applicability, and reduced cytotoxicity. Natural products have been an incomparable source of anticancer drugs in the modern era of drug discovery. Along with their derivatives and analogs, natural products play a major role in cancer treatment by modulating the cancer microenvironment and different signaling pathways. These compounds are effective against several signaling pathways, mainly cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch pathway, Wnt pathway, and Hedgehog pathway). The historical record of natural products is strong, but there is a need to investigate the current role of natural products in the discovery and development of cancer drugs and determine the possibility of natural products being an important source of future therapeutic agents. Many target-specific anticancer drugs failed to provide successful results, which accounts for a need to investigate natural products with multi-target characteristics to achieve better outcomes. The potential of natural products to be promising novel compounds for cancer treatment makes them an important area of research. This review explores the significance of natural products in inhibiting the various signaling pathways that serve as drivers of carcinogenesis and thus pave the way for developing and discovering anticancer drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Neoplasias / Antineoplásicos Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Qatar Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Neoplasias / Antineoplásicos Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Qatar Pais de publicación: Francia