The Effect of Yiqi Huoxue Tongluo Decoction on Spinal Cord Microglia Activation and ASK1-MKK3-p38 Signal Pathway in Rats with Diabetic Neuropathic Pain.

Wang, Fanjing; Tang, Heyong; Ma, Junlong; Cheng, Lianzhi; Lin, Yixuan; Zhao, Jindong; Shen, Guoming; Fang, Zhaohui; Jiang, Aijuan

Wang, Fanjing; Tang, Heyong; Ma, Junlong; Cheng, Lianzhi; Lin, Yixuan; Zhao, Jindong; Shen, Guoming; Fang, Zhaohui; Jiang, Aijuan.

Afiliación

Wang F; Department of Endocrine, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.
Tang H; School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Ma J; Anhui Jing'an Hospital of Integrated Traditional Chinese and Western Medicine, Hefei 230011, China.
Cheng L; School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Lin Y; Department of Endocrine, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.
Zhao J; Department of Endocrine, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.
Shen G; School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Fang Z; Department of Endocrine, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.
Jiang A; Diabetes Institute, Anhui Academy of Chinese Medicine, Hefei 230038, China.

Evid Based Complement Alternat Med ; 2022: 2408265, 2022.

Article en En | MEDLINE | ID: mdl-35646150

RESUMEN

Diabetic neuropathic pain (DNP) is one of the most common chronic peripheral neuropathies in diabetes mellitus (DM). Objective. To observe the underlying mechanism of the effects of Yiqi Huoxue Tongluo Decoction (YQHX) on DNP rats. Methods. SD rats were intraperitoneally injected with 35 mg/kg streptozotocin (STZ) to prepare DNP models and were treated with YQHX for 8 weeks. Results. Studies have shown that the drug restores some levels of MWT, TWL, and MNCV, downregulates the levels of inflammatory factors IL-6, IL-1ß, and TNF-α, downregulates the levels of ASK1-MKK3-p38, and weakens the level of OX42 activation. Conclusion. Yiqi Huoxue Tongluo Decoction can relieve DNP by affecting the activity of spinal cord microglia and the ASK1-MKK3-p38 signaling pathway, thereby reducing the central sensitization caused by the inflammatory response of DNP rats.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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